摘要
目的:观察小儿热速清颗粒联合布地奈德治疗肺炎支原体肺炎(MPP)患儿的效果。方法:选取2023年6月至2025年6月该院收治的108例MPP患儿进行前瞻性研究,根据随机数字表法将其分为对照组与观察组各54例。对照组给予布地奈德治疗,观察组在对照组基础上联合小儿热速清颗粒治疗。比较两组临床疗效,临床症状消失时间,治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平、中医证候积分,以及不良反应发生率。结果:观察组治疗总有效率为92.59%,高于对照组的75.93%,差异有统计学意义(P<0.05);观察组发热、咳嗽、气促、肺部啰音等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6、CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小儿热速清颗粒联合布地奈德治疗MPP患儿可提高治疗总有效率,缩短临床症状消失时间,以及降低炎性因子水平和中医证候积分的效果优于单纯布地奈德治疗。
Objective:To observe effects of Xiaoer Resuqing granules combined with Budesonide in treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods:A prospective study was conducted on 108 children with MPP admitted to this hospital from June 2023 to June 2025.According to the random number table method,they were divided into control group and observation group,54 cases in each group.The control group was treated with Budesonide,while the observation group was treated with Xiaoer Resuqing granules on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)],the TCM syndrome score,and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 92.59%,which was higher than 75.93%of the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as fever,cough,shortness of breath and lung rale in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-6 and CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TCM syndromes in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xiaoer Resuqing granules combined with Budesonide in the treatment of the children with MPP can improve the total effective rate of treatment,shorten the disappearance time of clinical symptoms,and reduce the levels of inflammatory factors and the TCM syndrome scores.Moreover,it is superior to simple Budesonide treatment.
作者
苏盈盈
杨伟琴
袁一
陈慧敏
SU Yingying;YANG Weiqin;YUAN Yi;CHEN Huimin(Department of Pediatrics of People’s Hospital of Huiji District,Zhengzhou 450044 Henan,China)
出处
《中国民康医学》
2026年第4期121-124,共4页
Medical Journal of Chinese People’s Health
关键词
肺炎支原体肺炎
小儿热速清颗粒
布地奈德
炎性因子
中医证候积分
不良反应
Mycoplasma pneumoniae pneumonia
Xiaoer Resuqing granules
Budesonide
Inflammatory factor
TCM syndrome score
Adverse reaction
