摘要
Complete collection of target fluids and effective capture of biomolecules are essential when designing and fabricating sensor electrodes.Assembling a conductive metal-organic framework(MOF)film onto a high-surfacearea porous aerogel to create a three-dimensional(3D)hierarchically ordered structure represented an effective strategy for fabricating sensor electrodes for body fluid detection.In this study,high-precision,confined growth of a self-assembled Cu-HHTP layer on an aerogel assisted by atomic layer deposition was employed to fabricate a hierarchical 3D-ordered metal-organic aerogel(MO A)electrode.This structure comprises two components:a conductive MOF thin film with abundant exposed active sites and a flexible 3D aerogel featuring through-holes with strong adsorption capacity,thereby enhancing liquid confinement and promoting biomolecule adsorption.This approach combines the aerogel's high flexibility and liquid adsorption ability with the conductive network of the CuHHTP film,thereby enabling an effective dopamine(DA)sensor.The sensor based on the 3D-ordered MO A electrode exhibits high sensitivity,with a detection limit of 1.19μM,along with excellent selectivity,stability,reproducibility,and strong anti-interference capability,as evidenced by negligible deviations in DA measurements across aqueous(H_(2)O)and fetal bovine serum(FBS)samples.A proof-of-concept test using human urine produces a pronounced response,confirming the sensor's practical feasibility.
基金
financially supported by the National Natural Science Foundation of China(No.52203328)
the Fundamental Research Funds for the Central Universities(Nos.2232024D-33 and 2232023A-10)
the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Major program(No.23M1060280)
Shanghai Pujiang Program(No.23PJ1400600)
