摘要
目的探究急性心肌梗死患者,在阿司匹林基础上应用替格瑞洛的治疗效果。方法本研究筛选80例患者,随机均分为单用组和联合组,单用组予以阿司匹林肠溶片,联合组在单用组加用替格瑞洛片。结果治疗前,2组患者的指标对比差异无统计学意义(P<0.05);治疗后,2组患者的LVEF提高,且联合组患者的LVEF高于单用组患者,2组患者的LVEDD、LVESD、Tei指数降低,且联合组患者的LVEDD、LVESD、Tei指数低于单用组患者;治疗前,2组患者的Plt、FIB、PT、APTT等指标对比差异无统计学意义(P<0.05);治疗后,2组患者的FIB降低,且联合组患者的FIB低于单用组患者,2组患者的Plt、PT、APTT提高,且联合组患者的Plt、PT、APTT高于单用组患者;联合组患者的治疗有效率为95.00%,高于单用组患者的80.00%;联合组患者的不良反应发生率为7.50%,低于单用组患者的12.50%。结论针对急性心肌梗死患者,应用替格瑞洛联合阿司匹林的治疗效果确切,对患者凝血功能、心肌功能恢复具有积极作用,安全性高。
Objective To investigate the therapeutic effect of ticagrelor on basis of aspirin for patients with acute myocardial infarction.Methods In this study,a total of 80 patients were selected and randomly equally divided into the monotherapy group and the combination group.The monotherapy group was given enteric-coated aspirin tablets,while the combination group was given ticagrelor tablets in addition to the monotherapy group.Results Before treatment,there was no statistically significant difference in the indicators between the two groups of patients(P<0.05).After treatment,the LVE of patients in both groups increased,and the LVEF of patients in the combined group was higher than that of the monotherapy group.The LVEDD,LVESD,and Tei indices of patients in both groups decreased,and the LVEDD,LVESD,and Tei indices of the patients in the combination group were lower than those of patients in the monotherapy group.Before treatment,there was no statistically significant difference in indicators such as Plt,FIB,PT,and APTT between the two groups of patients(P<0.05).After treatment,the FIB of patients in both groups decreased,and the FIB of patients in the combination group was lower than that of patients in the monotherapy group.The Plt,PT,and APTT of patients in both groups increased,and the Plt,PT,and APTT of patoents in the combination group were higher than those of patients in the monotherapy group.The treatment effective rate of the combination group was 95.00%,which was higher than 80.00%in the monotherapy group.The incidence of adverse reactions in the combination group was 7.50%,which was lower than 12.50%in the monotherapy group.Conclusions For patients with acute myocardial infarction,the therapeutic effect of ticagrelor combined with aspirin is definite,which has a positive effect on the recovery of patient's coagulation function and myocardial function,with high safety.
作者
梅彦霞
江竹君
邵俊
郭凌翔
MEI Yanxia;JIANG Zhujun;SHAO Jun;GUO Lingxiang(Emergency Department,Nanjing Tongren Hospital,Nanjing Jiangsu 211102,China;Cardiac and Great Vascular Disease Center,Subei people's Hospital,YANGzhou,Jiangsu 225001,China)
出处
《云南医药》
2026年第1期29-32,共4页
Medicine and Pharmacy of Yunnan
基金
江苏省卫生健康委科研项目(Z2020055)。
