摘要
目的:腺样体肥大(Adenoid Hypertrophy,AH)是儿童常见疾病,其发病机制复杂,传统中医药治疗虽具临床优势,但作用机制尚不明确。本研究基于现代医学“肺肠轴”学说与中医“肺与大肠相表里”理论,通过随机对照临床试验,探讨中药复方消腺汤雾化对AH的防治作用及潜在机制。方法:研究纳入160例AH患者,随机分为治疗组(消腺汤雾化,80例)与对照组(糠酸莫米松雾化,80例),观察临床疗效指标(通气指数)及机制性指标(肠道菌群结构、肠黏膜屏障功能、内毒素水平及炎症因子EOS、PAF、CysC)。采用免疫组织化学、16S rRNA测序及SPSS 26.0统计分析,明确消腺汤对肠道菌群失调的调节作用及其对肠黏膜屏障的保护效应。结果:消腺汤可显著改善患者通气功能(P<0.05),降低内毒素水平,修复肠黏膜结构,并上调益生菌丰度(如双歧杆菌、乳酸杆菌),抑制致病菌增殖(如大肠杆菌)。结论:消腺汤可能通过“肺-肠”交互通路,调控肠道菌群稳态,减轻肠源性内毒素血症,抑制炎症反应,从而缓解AH病理进程。本研究首次从“肺肠轴”角度系统阐释消腺汤多靶点干预AH的作用机制,为中医“肺与大肠相表里”理论提供现代医学证据,为中医药防治AH的临床转化奠定科学基础。
Objective:Adenoid Hypertrophy(AH)is a common disease in children with a complex pathogenesis.Although traditional Chinese medicine(TCM)treatment has clinical advantages,its mechanism of action remains unclear.Based on the modern medical theory of the"lung-gut axis"and the TCM theory of"the lung and large intestine being interior-exteriorly related",this study aimed to explore the preventive and therapeutic effects and potential mechanisms of nebulization with the Chinese herbal compound Xiaoxian Decoction on AH through a randomized controlled clinical trial.Methods:A total of 160 AH patients were enrolled and randomly divided into the treatment group(nebulization with Xiaoxian Decoction,80 cases)and the control group(nebulization with mometasone furoate,80 cases).Clinical efficacy indicators(ventilation index)and mechanistic indicators(intestinal flora structure,intestinal mucosal barrier function,endotoxin level,and inflammatory factors including EOS,PAF,and CysC)were observed.Immunohistochemistry,16S rRNA sequencing,and SPSS 26.0 statistical analysis were used to clarify the regulatory effect of Xiaoxian Decoction on intestinal dysbiosis and its protective effect on the intestinal mucosal barrier.Results:Xiaoxian Decoction significantly improved patients'ventilatory function(P<0.05),reduced endotoxin levels,repaired intestinal mucosal structure,upregulated the abundance of probiotics(e.g.,Bifidobacterium,Lactobacillus),and inhibited the proliferation of pathogenic bacteria(e.g.,Escherichia coli).Conclusion:Xiaoxian Decoction may alleviate the pathological process of AH by regulating intestinal flora homeostasis,reducing intestinal endotoxemia,and inhibiting inflammatory responses through the"lung-intestine"crosstalk pathway.This study is the first to systematically elucidate the mechanism of multi-target intervention of Xiaoxian Decoction in AH from the perspective of the"lung-gut axis",providing modern medical evidence for the TCM theory of"the lung and large intestine being interior-exteriorly related"and laying a scientific foundation for the clinical translation of TCM in the prevention and treatment of AH.
作者
田晓雨
于慧杰
王希军
TIAN Xiaoyu;YU Huijie;WANG xijun(Traditional Chinese Medicine Hall,Zibo City Integrated Traditional Chinese and Western Medicine Hospital,Zibo ,Shandong 255000,China)
出处
《内蒙古中医药》
2026年第2期109-113,共5页
Inner Mongolia Journal of Traditional Chinese Medicine
基金
山东省中医药科技重点项目(项目编号:Z-2023029)。
关键词
肺肠轴
腺体样肥大
肠道菌群
儿童
Lung-gut axis
Adenoid hypertrophy
Gut microbiota
Children
