摘要
心血管代谢疾病在全球范围内流行给个人和社会带来沉重负担。随着食品工业化加剧及环境新污染物在食品中迁移,食品中各种可能带来健康危害的因子暴露风险增加。越来越多研究表明,多种食品风险因子加剧心血管代谢疾病风险。由于食品风险因子种类繁多,暴露情况复杂,识别影响心血管代谢健康的高风险因子具有重要意义。本文调研近年来高质量人群流行病学和实验室研究证据,整理并分析具有代表性的食品风险因子包括:反式脂肪酸、甜味剂、乳化剂、微塑料、全氟/多氟烷基物、膳食糖基化终末产物等与心血管代谢疾病最新研究进展。讨论现有食品毒理学评价及风险评估局限,为制定科学合理的食品安全标准和心血管代谢疾病防控策略提供参考依据。
The global surge of cardiometabolic diseases poses a heavy burden to both individuals and society.With the rapid industrialization of the food system and the migration of emerging contaminants into food,the exposure risk of foodborne risk factors is increasing.Accumulating evidence suggests that multiple foodborne risk factors might accelerate the risk of cardiometabolic diseases.As the variety and complex exposure of risk factors,identification of those at high risk for cardiometabolic diseases is in urgent need.In this review,we summarize recent high-quality epidemiological and laboratory evidence,and analyze the latest research progress on representative foodborne risk factors associated with cardiometabolic diseases,including trans-fatty acids,artificial sweeteners,emulsifiers,micro-and nanoplastics,per-and polyfluoroalkyl substances(PFAS),and advanced glycation end products(AGEs).Limitations of current toxicological evaluation and risk assessment are further discussed,to provide scientific reference for establishment of food safety standard and prevention strategy for cardiometabolic diseases.
作者
赵立娜
黄贞贞
闻胜
Zhao Lina;Huang Zhenzhen;Wen Sheng(Department of Nutrition and Food Hygiene,School of Public Health,Wuhan University,Wuhan 430071,China;Department of Hygienic Toxicology,School of Public Health,Wuhan University,Wuhan 430071,China;Hubei Provincial Center for Disease Control and Prevention/National Health Commission's Characteristic Laboratory for Food Safety Risk Assessment and Standard Development,Wuhan 430079,China)
出处
《广西医科大学学报》
2026年第1期12-20,共9页
Journal of Guangxi Medical University
基金
国家重点研发计划课题资助项目(2024YFC3405804)。
关键词
食品风险因子
心血管代谢
风险评估
食品毒理学
反式脂肪酸
食品添加剂
新污染物
内分泌干扰物
foodborne risk factors
cardiometabolic diseases
risk assessment
food toxicology
trans-fatty acid
food additives
emerging contaminants
endocrine disruptors
