摘要
目的:探讨替格瑞洛联合阿司匹林在急性ST段抬高型心肌梗死(STEMI)经皮冠状动脉介入治疗(PCI)术后患者中的应用效果。方法:选取2023年1月—2024年12月于无锡市第二人民医院行急诊PCI的STEMI患者80例作为研究对象,采用计算机随机分配法分为参照组与分析组,各40例。两组均实施基础治疗,参照组采用氯吡格雷联合阿司匹林治疗,分析组采用替格瑞洛联合阿司匹林治疗。比较两组心肌酶谱、心功能指标、炎性因子水平。结果:治疗后,两组肌酸激酶、肌酸激酶同工酶、天冬氨酸氨基转移酶、乳酸脱氢酶水平均降低,且分析组低于参照组(P<0.001)。治疗后,两组左室射血分数、舒张早期峰值流速与舒张晚期峰值流速的比值均升高,左室舒张末期内径均减小,且分析组改善幅度大于参照组(P<0.05)。治疗后,两组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平均降低,且分析组低于参照组(P<0.001)。结论:替格瑞洛联合阿司匹林在STEMI PCI术后患者中的应用效果显著,可减轻患者心肌损伤与炎性反应,改善其心功能。
Objective:To explore the application effect of ticagrelor combined with aspirin in patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods:A total of eighty STEMI patients who underwent emergency PCI at Wuxi Second People's Hospital from January 2023 to December 2024 were selected as the research subjects.They were randomly divided into the reference group and the analysis group using computer-based randomization method,with forty cases in each group.Both groups received basic treatment.The reference group was treated with clopidogrel combined with aspirin,while the analysis group was treated with ticagrelor combined with aspirin.The levels of myocardial enzymes,cardiac function indicators,and inflammatory factors between the two groups were compared.Results:After treatment,the levels of creatine kinase,creatine kinase isoenzyme,aspartate aminotransferase,and lactate dehydrogenase in both groups decreased,and the levels in the analysis group were lower than those in the reference group(P<0.001).After treatment,the left ventricular ejection fraction,the ratio of peak early diastolic flow velocity to peak late diastolic flow velocity,and the left ventricular end-diastolic diameter in both groups increased,and the improvement in the analysis group was greater than that in the reference group(P<0.05).After treatment,the levels of C-reactive protein,tumor necrosis factor-α,and interleukin-6 in both groups decreased,and the levels in the analysis group were lower than those in the reference group(P<0.001).Conclusion:The application of ticagrelor combined with aspirin in patients after PCI for ST-segment elevation myocardial infarction(STEMI)shows significant effects,which can alleviate myocardial injury and inflammatory responses in patients,and improve their cardiac function.
作者
杨静
Yang Jing(Department of Cardiovascular Medicine,Wuxi Second People's Hospital(Jiangnan University Affiliated Central Hospital),Wuxi 214000,Jiangsu Province,China)
出处
《中国社区医师》
2026年第1期16-18,共3页
Chinese Community Doctors
