摘要
微流控芯片内复合液滴的形变特性分析对于细胞筛选以及药物输送等方面的研究具有重要参考价值。本文建立了黏性液滴和黏性细胞模型,利用VOF方法研究低韦伯数下复合液滴在微通道中挤压通过狭窄通道时的入口压力、剪切力等参数,进而得出复合液滴输运时的动力学特性。结果表明,韦伯数过高时,复合液滴稳定性降低,不利于其通过狭窄通道后恢复初始状态;而当韦伯数过低时,细胞偏移加剧致使其与载液直接接触,进而导致复合液滴破碎。
The deformation characteristics of compound droplets in microfluidic chips are of great reference value for research on cell screening and drug delivery.In this paper,a viscous droplet and viscous cell model are established.The VOF method is adopted to study the compound droplet’s inlet pressure,shear force,and other parameters when extruded through a narrow channel in a microchannel with a low Weber number to derive the kinetic properties of the compound droplet during transport.Results show that when the Weber number is high,the stability of compound droplets decreases,which is not conducive to the recovery of the initial state after passing through the narrow channel When the Weber number is too low,the cell deflection is intensified,resulting in direct contact between the cells and the carrier fluid,which leads to the fragmentation of the compound droplets.
作者
薛一帆
杨佳旺
何永清
杨薇
朱恒宣
杜鸿贤
王进
XUE Yifan;YANG Jiawang;HE Yongqing;YANG Wei;ZHU Hengxuan;DU Hongxian;WANG Jin(School of Energy and Environmental Engineering,Hebei University of Technology,Tianjin 300401,China;Chongqing Key Laboratory of Micro-Nano System and Intelligent Transduction,National Research Base of Intelligent Manufacturing Service,Chongqing Technology and Business University,Chongqing 400067,China;School of Materials Science and Engineering,Hebei University of Technology,Tianjin 300401,China)
出处
《工程热物理学报》
北大核心
2026年第2期561-567,共7页
Journal of Engineering Thermophysics
基金
国家自然科学基金(No.52176067)
河北省自然科学基金(No.E2022202139)。
关键词
微通道
复合液滴
韦伯数
细胞形变
microchannel
compound droplet
Weber number
cell deformation
