摘要
[目的]本文旨在探究不同剂量卡贝缩宫素对奶牛胎衣不下治疗效果、受胎率及初乳产量的影响,以期为该药在兽医临床的合理应用提供理论依据。[方法]试验选择120头健康荷斯坦牛,随机分为4组,对照组于分娩后10 min内肌注10 mL生理盐水,低、中、高剂量组分别肌注250、300、350μg/头卡贝缩宫素。观测并记录各组胎衣排出情况、排出时间、首次配种受胎率、初乳产量及血清炎性因子IL-1β、IL-6、TNF-α含量。[结果]结果显示,随卡贝缩宫素剂量增加,胎衣不下发生率逐渐下降,中、高剂量组发生率显著低于对照组(P<0.05);各治疗组首配受胎率显著高于对照组;初乳产量呈上升趋势但差异不显著;中剂量组血清炎性因子含量显著低于对照组。[结论]本试验表明,卡贝缩宫素可有效促进胎衣排出、提高受胎率,并可能降低产后炎症反应。推荐在临床中使用300μg/头作为兼顾疗效与经济性的适宜剂量。
[Objective]This study aimed to investigate the effects of different doses of carbetocin on the therapeutic efficacy for retained placenta,conception rate,and colostrum yield in dairy cows,in order to provide a theoretical basis for its rational clinical application in veterinary practice.[Method]A total of 120 healthy Holstein cows were selected and randomly divided into 4 groups.The control group received an intramuscular injection of 10 mL normal saline within 10 minutes postpartum.The low-,medium-,and high-dose groups received intramuscular injections of carbetocin at doses of 250,300,and 350μg per head,respectively.The placental expulsion status and time,first-service conception rate,colostrum yield,and serum levels of inflammatory factors(IL-1β,IL-6,TNF-α)were observed and recorded for each group.[Results]The results showed that as the dose of carbetocin increased,the incidence of retained placenta gradually decreased.The incidence in the medium-and high-dose groups was significantly lower than that in the control group(P<0.05).The first-service conception rate was significantly higher in all treatment groups compared to the control group.Colostrum yield showed an increasing trend with dose,but the differences were not statistically significant.The serum levels of inflammatory factors were significantly lower in the medium-dose group compared to the control group.[Conclusion]This experiment indicates that carbetocin can effectively promote placental expulsion,improve the conception rate,and may reduce postpartum inflammatory responses.A dose of 300μg per head is recommended for clinical use as an appropriate dose that balances efficacy and cost-effectiveness.
作者
刘玉平
张秀海
Liu Yuping;Zhang Xiuhai(Pingyin Veterinary Station,Pingyin Animal Husbandry and Veterinary Bureau,Jinan City,Shandong Province,Jinan Shandong 250400;Pingyin County Animal Husbandry Development Service Center,Jinan City,Shandong Province,Jinan Shandong 250400)
出处
《中国乳业》
2026年第1期71-76,共6页
China Dairy
关键词
卡贝缩宫素
奶牛
胎衣不下
受胎率
初乳产量
炎症因子
carbetocin
dairy cows
retained placenta
conception rate
colostrum yield
inflammatory factors
