摘要
目的:对比纳布啡联合环泊酚或丙泊酚在稳定性冠心病患者无痛胃镜检查中的应用效果。方法:选取2022年3月—2025年2月在深圳市第四人民医院行无痛胃镜检查的96例稳定性冠心病患者为研究对象,随机分为两组,每组48例。无痛胃镜检查中,丙泊酚组采用丙泊酚联合纳布啡麻醉方案,环泊酚组采用环泊酚联合纳布啡麻醉方案。比较两组血流动力学、麻醉与胃镜检查指标、心肌缺血指标及不良反应。结果:两组基线SBP、DBP、HR比较,差异无统计学意义(P>0.05);环泊酚组SBP、DBP、HR波动率低于丙泊酚组(P<0.05)。环泊酚组苏醒时间早于丙泊酚组,镇静药物使用剂量少于丙泊酚组(P<0.05);两组胃镜检查时间、体动发生率比较,差异无统计学意义(P>0.05)。两组ST段压低≥1 mm、心率血压乘积(RPP)>12000、麻醉苏醒24 h内胸痛发生率比较,差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在稳定性冠心病患者无痛胃镜检查中,相比丙泊酚联合纳布啡,使用环泊酚联合纳布啡麻醉有利于维持血流动力学稳定,可缩短苏醒时间,但两种麻醉方案发生心肌缺血及其他不良反应风险相当。
Objective:To compare the application effects of Nalbuphine combined with Cyclosporine or Propofol in painless gastroscopy for stable coronary heart disease patients.Method:A total of 96 stable coronary heart disease patients who underwent painless gastroscopy in Shenzhen Fourth People's Hospital from March 2022 to February 2025 were selected as the study subjects and randomly divided into two groups,with 48 cases in each group.During painless gastroscopy,the Propofol group received Propofol combined with Nalbuphine anesthesia,while the Cyclosporine group received Cyclosporine combined with Nalbuphine anesthesia.The hemodynamics,anesthesia and gastroscopy examination indicators,myocardial ischemia indicators,and adverse reactions were compared between two groups.Result:There were no statistically significant differences in baseline SBP,DBP and HR between the two groups(P>0.05).The fluctuation rates of SBP,DBP,and HR in the Cyclosporine group were lower than those in the Propofol group(P<0.05).The recovery time of the Cyclosporine group was earlier than that of the Propofol group,and the dosage of sedative drugs used was lower than that of the Propofol group(P<0.05).There were no statistical significant differences in the time of gastroscopy examination and the incidence of body movement between the two groups(P>0.05).There were no statistical significant differences in the comparison of ST segment depression≥1 mm,heart rate and blood pressure product(RPP)>12,000,and the incidence of chest pain within 24 hours after anesthesia recovery between the two groups(P>0.05).There was no statistical significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In painless gastroscopy of stable coronary heart disease patients,compared with Propofol combined with Nalbuphine,the use of Cyclosporine combined with Nalbuphine anesthesia can help maintain hemodynamic stability,shorten recovery time.However,the risk of myocardial ischemia and other adverse reactions is comparable between the two anesthesia regimens.
作者
李伟华
刘晓玲
胡小莉
陈潮世
LI Weihua;LIU Xiaoling;HU Xiaoli;CHEN Chaoshi(Department of Anesthesiology,Shenzhen Fourth People's Hospital,Shenzhen 518000,China;不详)
出处
《中国医学创新》
2026年第6期120-124,共5页
Medical Innovation of China
基金
深圳市萨米医疗中心院内课题临床研究项目(SSMC-2025-B2)。
关键词
冠心病
无痛胃镜
环泊酚
丙泊酚
纳布啡
Coronary heart disease
Painless gastroscopy
Cyclosporine
Propofol
Nalbuphine
