摘要
目的:观察锡类散联合红外线照射治疗对脓肿期骶尾部藏毛窦术后创面愈合的临床疗效及其机制研究。方法:符合入组标准的60例行切口开放手术的脓肿期骶尾部藏毛窦患者随机数字法分为观察组和对照组,每组各30例。换药时对照组仅采用凡士林纱布填塞创面,观察组采用锡类散外用+红外线照射+凡士林纱布联合干预,持续至术后3周,记录2组患者术后创面深度缩减率,比较2组创面症状评分(包括疼痛、出血、肉芽形态评分),检测2组患者术后血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)及血管内皮生长因子(VEGF)的水平。结果:2组患者术后2d创面症状评分、IL-10、TNF-α及VEGF的水平比较,差异均无统计学意义;观察组术后14d、21dTNF-α水平及症状评分均低于对照组,差异有统计学意义;术后7d、14d、21d创面深度缩减率、术后14d、21d血清IL-10、VEGF水平均高于对照组,差异有统计学意义。结论:锡类散联合红外线照射治疗能缓解脓肿期骶尾部藏毛窦患者术后痛感,降低出血风险,调节炎症反应,提高临床疗效,促进创面生长愈合。
Objective:To observe the clinical efficacy and mechanism of tin-based powder combined with infrared irradiation in the healing of sacrococcygeal pilonidal sinus surgery in the abscess stage.Methods:Sixty patients with sacrococcygeal pilonidal sinus surgery in the abscess stage who met the inclusion criteria were randomly divided into an observation group and a control group,with 30 patients in each group.During dressing changes,the control group only used Vaseline gauze to pack the wound,while the observation group received a combination of tin-based powder external application,infrared irradiation,and Vaseline gauze,which continued for 3 weeks postoperatively.The wound depth reduction rate was recorded in both groups,and the wound symptom scores(including pain,bleeding,and granulation morphology scores)were compared between the two groups.The levels of tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),and vascular endothelial growth factor(VEGF)in the serum of both groups were measured postoperatively.Results:There were no statistically significant differences in wound symptom scores,IL-10,TNF-α,and VEGF levels between the two groups at 2 days post-operation.The observation group showed significantly lower TNF-αlevels and symptom scores at 14 and 21 days post-operation compared to the control group.The observation group also showed significantly higher wound depth reduction rates,serum IL-10,and VEGF levels at 14 and 21 days post-operation compared to the control group.Conclusion:Xileisan combined with infrared irradiation can alleviate postoperative pain,reduce bleeding risk,regulate inflammatory response,improve clinical efficacy,and promote wound healing in patients with sacrococcygeal pilonidal sinus abscess.
作者
朱子玉
李明
查德华
ZHU Ziyu;LI Ming;ZHA Dehua(Anhui University of Chinese Medicine,Anhui Hefei 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)
出处
《中医药临床杂志》
2025年第12期2540-2544,共5页
Clinical Journal of Traditional Chinese Medicine
基金
国家中医优势专科肛肠科建设项目(zyyfw20230048)。
关键词
脓肿期骶尾部藏毛窦
锡类散
红外线
创面愈合
炎症反应
Sacrococcygeal pilonidal sinus abscess
Xileisan
Infrared irradiation
Wound healing
Inflammatory response
