摘要
近年来,随着医疗器械及生物制药技术的迅猛发展,胃癌外科的治疗模式正经历着巨大的变革。从传统开腹的手术模式到依托腹腔镜、机器人等设备的微创手术模式,3D和4K高清影像与荧光导航的"精创"系统大大拓展了外科医生的能力边界。而在肿瘤高通量组学分子分型的理论支撑下,免疫和靶向等新型药物的临床应用,进一步改变了胃癌的治疗格局,转化治疗的发展使局部晚期或远处转移的胃癌患者显著改善了疗效及预后,将手术与化疗、放疗、靶向治疗、免疫治疗等手段相结合的综合治疗模式已成为趋势。外科手术的作用正在被重新定义,在保证肿瘤学疗效的前提下,器官和功能保留理念获得了更多的重视。在胃癌诊疗模式不断演进的背景下,多学科团队诊疗(MDT)与医患共同决策(SDM)模式的建立与实践,已成为提升胃癌诊疗质量和改善患者预后的有效保障。相信人工智能等前沿科技与临床医学的深度融合,将会使胃癌诊疗更加快速地步入精准化时代。
In recent years,with the rapid development of medical device and biopharmaceutical technologies,the treatment model of gastric cancer surgery has been undergoing tremendous transformations.From the traditional open surgery model to the minimally invasive surgery model supported by devices such as laparoscopes and robots,the"precision minimally invasive"system integrated with 3D/4K high-definition imaging and fluorescent navigation has greatly expanded the capability boundaries of surgeons.Supported by the theory of high-throughput omics-based molecular typing of tumors,the clinical application of novel drugs such as immunotherapeutics and targeted drugs has further reshaped the treatment landscape of gastric cancer.The advancement of conversion therapy has significantly improved the therapeutic efficacy and prognosis of patients with locally advanced or distant metastatic gastric cancer,and the comprehensive treatment model that combines surgery with chemotherapy,radiotherapy,targeted therapy,immunotherapy and other modalities has become a mainstream trend.The role of surgical procedures is being redefined,and the concept of organ and function preservation has gained greater attention on the premise of ensuring oncological efficacy.Against the backdrop of the continuous evolution of gastric cancer diagnosis and treatment models,the establishment and practice of multidisciplinary treatment(MDT)and shared decision-making(SDM)models have become effective guarantees for enhancing the quality of gastric cancer diagnosis and treatment and improving patient prognosis.It is believed that the in-depth integration of cutting-edge technologies such as artificial intelligence with clinical medicine will enable the diagnosis and treatment of gastric cancer to enter the era of precision more rapidly.
作者
李子禹
贾永宁
唐小欢
Li Ziyu;Jia Yongning;Tang Xiaohuan(Gastrointestinal Tumor Center,Peking University Cancer Hospital&Institute,Beijing Institute for Cancer Research,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Beijing 100142,China)
出处
《中华胃肠外科杂志》
北大核心
2026年第1期10-17,共8页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肿瘤
外科
诊疗模式
Stomach neoplasms
Surgery
Treatment model
