摘要
目的观察六君子汤联合西医治疗对非小细胞肺癌(NSCLC)术后慢性咳嗽患者中医证候及肺功能的影响。方法选择2022年3月—2025年3月辽宁中医药大学附属医院收治的NSCLC术后慢性咳嗽患者92例,按随机数字表法分为观察组和对照组,各46例。对照组予以西医常规治疗,观察组在对照组基础上联合六君子汤治疗,2组均持续治疗4周。比较2组临床疗效,治疗前后中医证候积分、肺功能[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]、炎性因子[白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]及不良反应。结果观察组治疗总有效率(95.65%)高于对照组(82.61%)(χ^(2)=4.039,P=0.045)。治疗4周后,2组咳嗽反复发作、咳声低弱、痰多色白质稀积分低于治疗前,且观察组低于对照组(P<0.01);2组FEV_(1)、FVC、FEV_(1)/FVC高于治疗前,且观察组高于对照组(P<0.05或P<0.01);2组IL-6、CRP、TNF-α水平低于治疗前,且观察组低于对照组(P<0.01)。观察组与对照组不良反应总发生率比较差异无统计学意义(17.39%vs.13.04%,χ^(2)=0.337,P=0.562)。结论六君子汤联合西医治疗NSCLC术后慢性咳嗽患者疗效确切,可有效减轻其临床症状及炎性反应,促进肺功能改善,且不会明显增加不良反应。
Objective To observe the effect of Liujunzi decoction combined with western medicine on TCM syndromes and lung function of patients with chronic cough after non-small cell lung cancer(NSCLC)surgery.Methods Ninety-two pat ients with postoperative chronic cough of NSCLC admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 2022 to March 2025 were selected and randomly divided into observation group and control group,46 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with Liujunzi decoction on the basis of the control group,both groups were treated for 4 weeks.The clinical efficacy,TCM syndrome scores,lung function(FEV_(1),FVC,FEV_(1)/FVC),inflammatory factors(IL-6,CRP,TNF-α)before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(95.65%)was higher than that of the control group(82.61%)(χ^(2)=4.039,P=0.045).After 4 weeks of treatment,the scores of recurrent cough,low cough sound,sputum polychromatic white matter rarefaction in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.01).The FEV_(1),FVC,FEV_(1)/FVC of the two groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05 or P<0.01).The levels of IL-6,CRP and TNF-αin the two groups were lower than those be fore treatment,and those in the observation group were lower than those in the control group(P<0.01).There was no sign ificant difference in the total incidence of adverse reactions between the observation group and the control group(17.39%vs.13.04%,χ^(2)=0.337,P=0.562).Conclusion Liujunzi decoction combined with Western medicine in the treatment of pa tients with chronic cough after NSCLC surgery has definite curative effect,which can effectively reduce the clinical symp toms and inflammatory reactions,promote the improvement of lung function,and will not significantly increase the adv erse r eactions.
作者
刘家良
郑凯
LIU Jialiang;ZHENG Kai(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;不详)
出处
《临床合理用药》
2026年第6期4-8,共5页
Chinese Journal of Clinical Rational Drug Use
基金
第一批辽宁省中医临床优秀人才项目(2024-JYTCB-113)。
关键词
慢性咳嗽
非小细胞肺癌
术后
六君子汤
西医治疗
中医证候
肺功能
炎性因子
不良反应
Chronic cough
Non-small cell lung cancer
Postoperative
Liujunzi decoction
Western medicine tre atment
TCM syndrome
Lung function
Inflammatory factors
Adverse reactions
