摘要
目的观察阿托伐他汀钙治疗蛛网膜下腔出血的效果及对血管内皮功能的影响。方法选择2021年4月—2023年3月于上饶市人民医院接受治疗的蛛网膜下腔出血患者106例,采用随机数字表法分为观察组(n=53)和对照组(n=53)。对照组给予尼莫地平治疗,观察组在对照组基础上给予阿托伐他汀钙治疗,2组均治疗30 d。比较2组临床疗效,治疗前后血管内皮功能指标[一氧化氮(NO)、内皮素(ET)]、脑血流指标[大脑中动脉平均流速(MCA-V_(m))、颈内动脉颅外段平均流速(EICA-V_(m))]、美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分及不良反应。结果观察组总有效率为90.57%,高于对照组的75.47%(χ^(2)=4.283,P=0.038)。治疗30 d后,2组NO水平高于治疗前,ET水平低于治疗前,且观察组变化幅度大于对照组(P<0.01);2组MCA-V_(m)、EICA-V_(m)低于治疗前,且观察组低于对照组(P<0.05或P<0.01);2组NIHSS评分低于治疗前,GCS评分高于治疗前,且观察组变化幅度大于对照组(P<0.01)。观察组与对照组不良反应总发生率比较差异无统计学意义(9.43%vs.7.55%,χ^(2)=0.121,P=0.727)。结论阿托伐他汀钙治疗蛛网膜下腔出血效果较好,可改善患者血管内皮功能与脑血流,减轻神经功能损伤,且安全性较高。
Objective To observe the effect of atorvastatin calcium in the treatment of subarachnoid hemorrhage and its effect on vascular endothelial function.Methods A total of 106 patients with subarachnoid hemorrhage treated in Shangrao People′s Hospital from April 2021 to March 2023 were selected and randomly divided into observation group(n=53)and control group(n=53).The control group was treated with nimodipine,and the observation group was treated with atorvastatin calcium on the basis of the control group,both groups were treated for 30 days.The clinical efficacy,vascular e ndothelial function indexes(NO,ET),cerebral blood flow indexes(MCA-V_(m),EICA-V_(m)),NIHSS score,GCS score before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of the o bservation group was 90.57%,which was higher than 75.47%of the control group(χ^(2)=4.283,P=0.038).After 30 days of treatment,NO levels in the two groups were higher than those before treatment,ET levels were lower than those before t reatment,an d the change amplitude of the observation group was greater than that of the control group(P<0.01).MCA-V_(m) and EICA-V_(m) in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05 or P<0.01).The NIHSS scores of the two groups were lower than those before treatment,and the GCS scores were higher than those before treatment,and the change amplitude of the observation group was greater than that of the control group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group(9.43%vs.7.55%,χ^(2)=0.121,P=0.727).Conclusion Atorvastatin calcium in the treatment of subarachnoid hemorrhage has a better effect,which can improve the vascular endothelial function and c erebral blood flow of patients,reduce neurological injury,and has a high safety.
作者
姜志荣
王志勇
JIANG Zhirong;WANG Zhiyong(Department of Trauma Center,Shangrao People′s Hospital,Jiangxi Province,Shangrao 334000,China)
出处
《临床合理用药》
2026年第6期1-3,8,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
蛛网膜下腔出血
阿托伐他汀钙
血管内皮功能
脑血流
不良反应
Subarachnoid hemorrhage
Atorvastatin calcium
Vascular endothelial function
Cerebral blood flow
A dverse reactions
