摘要
目的明确益气活血开窍组分中药对急性脑梗死(acute cerebral infarction,ACI)患者临床疗效及脑保护作用。方法选取ACI住院患者150例,随机分为治疗组(75例)与对照组(75例)。对照组采用常规治疗,治疗组在对照组基础上口服益气活血开窍组分中药。观察两组治疗前后国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)、MRS评分(改良Rankin量表,Modified Rankin Scale,MRS)及血清神经元特异性烯醇化酶(serum levels of neuron-specific enolase,SNE)、血清S-100B蛋白、血清血管性假血友病因子(von Willebrand factor,vWF)、血浆内皮素1(endothelin-1,ET-1)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)含量的变化。结果治疗组总有效率90.67%(68/75),对照组总有效率76.00%(57/75),治疗组优于对照组(P<0.05)。治疗后,治疗组NIHSS、MRS评分较对照组显著下降(P<0.05)。治疗组SNE、S-100B、vWF、ET-1、IL-1β、IL-6水平显著低于对照组(P<0.05)。结论益气活血开窍组分中药治疗ACI具有良好地保护脑神经、减轻脑损伤、改善血管内皮功能、抑制炎症作用。
Objective To determine the clinical efficacy and neuroprotective effects of Qi-benefiting and blood-activating open-orifice traditional Chinese medicine components in patients with acute cerebral infarction(ACI).Methods A total of 150 hospitalized patients with acute cerebral infarction(ACI)were selected and randomly divided into a treatment group(75 cases)and a control group(75 cases).The control group received the standard treatment,while the treatment group received oral administration of Qi-benefiting and blood-activating open-orifice traditional Chinese medicine components in addition to standard treatment.Both groups were evaluated before and after treatment using the National Institutes of Health Stroke Scale(NIHSS),Modified Rankin Scale(MRS)and the changes in serum levels of neuron-specific enolase(SNE),serum S-100B protein,serum von Willebrand factor(vWF),plasma endothelin-1(ET-1),IL-1βand IL-6.Results The overall effectiveness rate was 90.67%(68/75)in the treatment group and 76.00%(57/75)in the control group,with the treatment group showing significant superiority(P<0.05).After treatment,there was a significant reduction in NIHSS and MRS scores in the treatment group compared to those in the control group(P<0.05).Additionally,the levels of SNE,S-100B,vWF,ET-1,IL-1βand IL-6 were significantly lower in the treatment group than those in the control group(P<0.05).Conclusion The treatment of ACI with Qi-benefiting and blood-activating open-orifice traditional Chinese medicine components effectively protects the nerve cells,mitigates the brain damage,improves the vascular endothelial function and inhibits the inflammation.
作者
刘畅
陈心怡
杨阳
黄剑涛
唐艳
LIU Chang;CHEN Xinyi;YANG Yang;HUANG Jiantao;TANG Yan(Changde First Traditional Chinese Medicine Hospital,Changde 415100,Hunan,China)
出处
《辽宁中医杂志》
北大核心
2026年第2期122-125,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
湖南创新型省份建设专项项目(2021ZK4336)
湖南中医药大学2021年度校级科研基金与联合基金项目(2021XJJJ071)。
关键词
急性脑梗死
益气活血开窍组分中药
脑保护
内皮功能
炎症
acute cerebral infarction
Qi-benefiting and blood-activating open-orifice traditional Chinese medicine components
neurological deficit scoring
endothelial function
inflammation
