摘要
目的评价加味益气养阴方联合运动处方治疗气阴两虚型非小细胞肺癌癌因性疲乏(cancer-related fatigue,CRF)的临床疗效。方法将80例首诊为气阴两虚型非小细胞肺癌CRF患者,随机分为治疗组和对照组各40例。两组患者在抗肿瘤治疗的基础上,分别给予运动处方、加味益气养阴方联合运动处方治疗,共治疗2个月,比较两组治疗前后Piper疲乏量表、中医证候学评分、卡氏(Karnofsky performance status,KPS)评分、肿瘤患者生存质量评定量表(quality of life,QOL)各项评分,并观察患者血常规、肝肾功能、T细胞亚群等客观指标治疗前后的变化情况。结果(1)治疗组脱落5例,对照组脱落3例,共完成试验者72例,其中治疗组35例,对照组37例。(2)临床疗效评价:两组治疗后Piper量表各项评分、中医证候学评分均较同组治疗前显著降低(P<0.05);KPS评分、QOL评分均较同组治疗前显著升高(P<0.05)。治疗组治疗前后各项评分的差值明显高于对照组(P<0.05)。(3)免疫功能评估:治疗组治疗前后白蛋白、CD3细胞占淋巴细胞比例、Th细胞占淋巴细胞比例的差值与对照组相比明显升高(P<0.05),余均无改善。(4)安全性评价:治疗组治疗前后白细胞、中细粒细胞、血红蛋白、血小板及粒淋比数值比较,差异均无统计学意义(P>0.05);与对照组比较,差异均无统计学意义(P>0.05)。结论加味益气养阴方联合运动处方可明显改善非小细胞肺癌患者疲乏状态及生活质量,提高辅助T淋巴细胞比例,促进患者免疫功能的恢复,且安全性良好。
Objective To evaluate the clinical efficacy of Modified Yiqi Yangyin Formula(加味益气养阴方)combined with exercise prescription in the treatment of cancer-related fatigue(CRF)in non-small cell lung cancer with Qi and Yin deficiency.Methods Eighty patients with CRF of non-small cell lung cancer diagnosed as Qi and Yin deficiency at the first diagnosis were randomly divided into the treatment group and the control group with 40 cases in each.On the basis of basic antitumor treatment,the patients in both groups were given exercise prescription and Modified Yiqi Yangyin Formula combined with exercise prescription treatment respectively,with 4 weeks as one treatment cycle and two cycles of treatment in total,comparing the scores of Piper′s fatigue scale,traditional Chinese medicine diagnosis and diagnosis,Karnofsky Performance Status(KPS)score and quality of life(QOL)scale before and after the treatment of the two groups and observing objective indexes such as blood routine,liver and kidney function,T-cell subpopulation and other indicators before and after the treatment.cell subpopulations and other objective indicators before and after treatment.Results(1)There were 5 cases of shedding in the treatment group and 3 cases in the control group,and a total of 72 cases were completed,including 35 cases in the treatment group and 37 cases in the control group.(2)Evaluation of clinical efficacy:The scores of Piper scale and traditional Chinese medicine syndrome scores of the two groups after treatment were significantly lower than those before treatment of the same group(P<0.05).The KPS scores and QOL scores were significantly higher than those before treatment of the same group(P<0.05).The difference between the scores before and after treatment was significantly higher in the treatment group than that in the control group(P<0.05).(3)Assessment of immune function:The difference of albumin,the proportion of CD3 cells to lymphocytes and the proportion of Th cells to lymphocytes in the treatment group was significantly higher compared with that in the control group(P<0.05),and the rest did not improve.(4)Safety evaluation:Comparison of the values of leukocytes,medium and fine granulocytes,haemoglobin,platelets and granulocyte ratio before and after treatment in the treatment group showed no statistical difference(P>0.05).Compared with the control group,the differences were not statistically significant(P>0.05).Conclusion Modified Yiqi Yangyin Formula and exercise prescription can significantly improve the fatigue state and quality of life of non-small cell lung cancer patients,increase the proportion of auxiliary T-lymphocytes and promote the recovery of patients′nutritional state and immune function,and the safety is good.
作者
赵瑞国
解建国
崔晓楠
陈海玉
陆依珊
高平
ZHAO Ruiguo;XIE Jianguo;CUI Xiaonan;CHEN Haiyu;LU Yishan;GAO Ping(The Second Hospital Attatched to Liaoning University of TCM,Shengyang 110031,Liaoning,China;First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning,China;Institute of Integrated Traditional Chinese and Western Medicine,Dalian Medical University,Dalian 116044,Liaoning,China)
出处
《辽宁中医杂志》
北大核心
2026年第2期112-118,I0002,共8页
Liaoning Journal of Traditional Chinese Medicine
基金
湖北陈孝平科技发展基因会肿瘤领域临床研究专项基金项目(CXPJJH122011-016)。
关键词
加味益气养阴方
非小细胞肺癌
疲乏
气阴两虚
T淋巴亚群
Modified Yiqi Yangyin Formula(加味益气养阴方)
non-small cell lung cancer
fatigue
deficiency of both Qi and Yin
T lymphocyte subsets
