摘要
脂质体是一种功能丰富的人造材料,具有较好的稳定性、较高的包载性以及良好的生物相容性。外泌体是细胞分泌产生的一类天然纳米级的囊泡,包载多种内源性物质,能作为药物对疾病产生治疗作用又可作为药物递送载体,具有极好的生物相容性和靶向递送能力。尽管脂质体和外泌体在医药领域的价值已经有了一定程度的开发,但由于二者单独应用具有一定的局限性,因此本综述从二者具有的特性出发,总结和分析了脂质体促细胞外泌体分泌的应用、脂质体-外泌体在药物递送中的应用以及在疾病检测与诊断中的应用,进而为脂质体和外泌体在医药领域的进一步开发提供研究思路。
Liposomes are functional artificial materials with good stability,high encapsulation efficiency and good biocompatibility.Containing various endogenous substances,exosmes are a type of natural nanoscale vesicles secreted by cells,which could be used as a drug to treat diseases and a drug delivery carrier with excellent biocompatibility and targeted delivery ability.Although the value of liposomes and exosomes in the pharmaceutical fields had been developed to a certain extent,the application for each individual had certainlimitations.Therefore,this paper summarizes and analyzes the applications of liposomes in promoting exosome secretion,liposome-exosome in drug delivery and disease detection and diagnosis.So the thoughts for further development of liposomes and exosomes in the medication field might be provided.
作者
王学丽
刘杰峰
和卓怡
冯光涯
鲁卫东
WANG Xueli;LIU Jiefeng;HE Zhuoyi;FENG Guangya;LU Weidong(School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China)
出处
《药物生物技术》
2025年第6期857-861,共5页
Pharmaceutical Biotechnology
关键词
脂质体
外泌体
产量
制备
药物递送
疾病诊断
Liposomes
Exosomes
Yield
Preparation
Drug delivery
Disease diagnosis
