摘要
目的观察风寒湿痹证膝骨关节炎性滑膜炎患者应用桂枝芍药知母汤加减的辅助效果。方法选择我院2022年11月至2023年12月收治的风寒湿痹证膝骨关节炎性滑膜炎患者102例为研究对象,随机分为对照组和观察组,每组51例。对照组接受常规治疗和体外冲击波,观察组在对照组治疗基础上加服桂枝芍药知母汤加减。比较两组疗效、中医症候总积分、西安大略和麦克马斯特大学骨关节炎指数(western ontario and McMaster universities osteoarthritis index,WOMAC)评分、美国特种外科医院膝关节评分(hospital for special surgery knee score,HSS)关节积液评分及滑膜厚度评分、血清炎症因子水平变化及不良反应发生情况。结果治疗后,观察组治疗总有效率高于对照组(94.12%vs.80.39%,P<0.05)。观察组治疗后中医症候总积分、WOMAC评分、HSS评分、关节积液评分和滑膜厚度评分均优于对照组,炎症因子水平均低于对照组,差异显著(P<0.05)。观察组不良反应发生率低于对照组(3.92%vs.5.88%),但无显著差异(P>0.05)。结论桂枝芍药知母汤加减辅助治疗风寒湿痹证膝骨关节炎性滑膜炎患者效果良好,安全可靠。
Objective To observe the adjuvant effect of modified Guizhi Shaoyao Zhimu decoction on patients with knee osteoarthritic synovitis of wind-cold-damp arthralgia syndrome.Methods A total of 102 patients with knee osteoarthritic synovitis of wind-cold-damp arthralgia syndrome who were admitted to our hospital from November 2022 to December 2023 were selected as the research subjects and randomly divided into the control group and the observation group,with 51 cases in each group.The control group received conventional treatment and extracorporeal shock wave therapy,while the observation group was given modified Guizhi Shaoyao Zhimu decoction on the basis of the treatment of the control group.The therapeutic effects,total score of traditional Chinese medicine(TCM)symptoms,western ontario and McMaster universities osteoarthritis index(WOMAC)score,hospital for special surgery knee score(HSS),joint effusion score,synovial thickness score,changes in serum inflammatory factor levels and occurrence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group(94.12%vs.80.39%,P<0.05).After treatment,the total score of TCM symptoms,WOMAC score,HSS,joint effusion score and synovial thickness score of the observation group were all better than those of the control group,and the levels of inflammatory factors were all lower than those of the control group,with significant differences(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(3.92%vs.5.88%),but there was no significant difference(P>0.05).Conclusion The modified Guizhi Shaoyao Zhimu decoction has a good effect and is safe and reliable in the adjuvant treatment of patients with knee osteoarthritic synovitis of wind-cold-damp arthralgia syndrome.
作者
艾柯
王雷
杨军
陈杰能
AI Ke;WANG Lei;YANG Jun;CHEN Jieneng(Department of Orthopedic Ward,Huanggang Dabieshan Medical Center,Huanggang 438000,Hubei Province,China;Department of Neurology,Huanggang Dabieshan Medical Center,Huanggang 438000,Hubei Province,China;Health Management Center,Huanggang Dabieshan Medical Center,Huanggang 438000,Hubei Province,China;Department of Ultrasound Medicine,Huanggang Central Hospital,Huanggang Dabieshan Medical Center,Huanggang 438000,Hubei Province,China)
出处
《世界临床药物》
2025年第12期1237-1242,共6页
World Clinical Drug
基金
湖北省自然科学基金(2021CFB530)。
关键词
膝骨关节炎性滑膜炎
风寒湿痹证
桂枝芍药知母汤
体外冲击波
膝关节功能
炎症因子
knee osteoarthritic synovitis
wind-cold-damp arthralgia syndrome
Guizhi Shaoyao Zhimu decoction
extracorporeal shock wave
knee joint function
inflammatory factor
