摘要
溃疡性结肠炎(UC)是一种发生于肠道的自身免疫性疾病,随着UC发病率逐渐上升,对其发病机制也进行了不断的探讨。多数研究认为UC的发病机制是多样的,与遗传、免疫炎症反应以及环境因素均有关,UC具有病程长、反复发作的特点,严重影响了患者的生活质量。本文通过查阅与UC相关的文献,全面整合与UC相关的血清和组织因子进行综述,明确UC患者血清及组织学中相关因子的表达水平并进行相关性探讨,可进一步明确UC的疾病分期及严重程度,对于UC的预后进行正确评估,为进一步研究UC相关通路和潜在免疫学治疗靶点提供依据,同时为UC的机制研究和治疗方案提供新的思路和方法。
Ulcerative colitis(UC)is an autoimmune disease that occurs in the intestine.With the increasing incidence of UC,its pathogenesis has also been continuously explored.Most studies suggest that the pathogenesis of UC is diverse,which is related to genetic,immune inflammatory response and environmental factors.UC has the characteristics of long course of disease and repeated attacks,which seriously affects the quality of life of patients.In this paper,we reviewed the literature related to UC,comprehensively integrated the serum and tissue factors related to UC,and clarified the expression levels of related factors in serum and histology of UC patients and discussed the correlation.It can further clarify the disease stage and severity of UC,correctly evaluate the prognosis of UC,provide a basis for further study of UC-related pathways and potential immunological therapeutic targets,and provide new ideas and methods for UC mechanism research and treatment programs.
作者
薛林岩
李艳梅
XUE Linyan;LI Yanmei(Department of Gastroenterology,Inner Mongolia Medical University Affiliated Hospital,Hohhot 010050,Inner Mongolia,China)
出处
《医学信息》
2026年第2期181-185,192,共6页
Journal of Medical Information
基金
内蒙古医科大学附属医院院级课题(编号:2022NYFYTS009)
内蒙古医科大学青年项目(编号:YKD2023QN028)。
关键词
溃疡性结肠炎
血清炎性因子
组织相关基因
表达水平
Ulcerative colitis
Serum inflammatory factors
Tissue-related gene
Expression levels
