摘要
目的:探讨依达拉奉右莰醇联合康复模式在急性脑梗死中的应用效果。方法:回顾性选择2022年1月—2025年1月苏州市相城人民医院神经内科收治的128例急性脑梗死患者,根据治疗方法将其分为48 h组43例、2周组43例与对照组42例。对照组单纯使用依达拉奉右莰醇治疗,48 h组在对照组基础上发病48 h内启动康复模式,2周组在对照组基础上发病2周后启动康复模式。比较三组NIHSS评分、中性粒细胞和淋巴细胞比值(NLR)、简易精神状态检查量表(MMSE)、改良Rankin量表(mRS)评分、改良曼恩吞咽能力量表(modified Mann assessment of swallowing ability,MMASA)评分与深静脉血栓(DVT)发生率、肺部感染发生率。结果:发病3个月后,三组NIHSS评分及NLR较入院时显著降低,MMSE评分较入院时升高(P<0.05)。发病3个月后,48 h组的NIHSS评分及NLR低于2周组与对照组,48 h组的MMSE评分高于2周组与对照组(P<0.05)。发病3个月后,三组mRS评分较入院时显著降低,MMASA评分较入院时显著升高(P<0.05)。发病3个月后,48 h组mRS评分低于2周组与对照组,MMASA评分高于2周组与对照组(P<0.05)。三组肺部感染与DVT发生率对比差异有统计学意义(P<0.05),其中对照组肺部感染与DVT发生率最高。结论:依达拉奉右莰醇联合康复模式可以促进急性脑梗死患者神经、认知功能与自理能力恢复,降低了炎症水平与DVT及肺部感染发生率,发病48 h内启动康复模式,患者获益更多。
Objective:To explore the application effect of the Edaravone and Dexborneol combined with rehabilitation model in acute cerebral infarction.Method:A total of 128 patients with acute cerebral infarction admitted to the Department of Neurology,Xiangcheng People's Hospital of Suzhou City from January 2022 to January 2025 were retrospectively selected.According to the treatment methods,they were divided into 43 cases in the 48 h group,43 cases in the 2-week group and 42 cases in the control group.The control group was treated with Edaravone and Dexborneol alone,the 48 h group initiated the rehabilitation model within 48 hours after the onset of the disease on the basis of the control group,and the 2-week group initiated the rehabilitation model 2 weeks after the onset of the disease on the basis of the control group.The NIHSS score,neutrophil-to-lymphocyte ratio(NLR),mini-mental state examination scale(MMSE),modified Rankin scale(mRS)score,and modified Mann assessment of swallowing ability(MMASA)and the incidence of deep vein thrombosis(DVT)and pulmonary infection were compared among the three groups.Result:Three months after the onset of the disease,the NIHSS scores and NLR of the three groups were significantly lower than those at admission,and the MMSE scores were higher than those at admission(P<0.05).Three months after the onset of the disease,the NIHSS score and NLR in the 48 h group were lower than those in the 2-week group and the control group,while the MMSE score in the 48 h group was higher than that in the 2-week group and the control group(P<0.05).Three months after the onset of the disease,the mRS score of the three groups were significantly lower than those at admission,and the MMASA scores were significantly higher than those at admission(P<0.05).Three months after the onset of the disease,the mRS score of the 48 h group was lower than that of the 2-week group and the control group,and the MMASA score was higher than that of the 2-week group and the control group(P<0.05).There were statistically significant differences in the incidence of pulmonary infection and DVT among the three groups(P<0.05),among which the incidence of pulmonary infection and DVT was the highest in the control group.Conclusion:Edaravone and Dexborneol combined with rehabilitation model can promote the recovery of neurological,cognitive functions and self-care abilities in patients with acute cerebral infarction,reduce the level of inflammation and the incidence of DVT and pulmonary infection.If the rehabilitation model is initiated within 48 hours of onset,patients will benefit more.
作者
韩晓云
丁猛猛
解力
李永安
HAN Xiaoyun;DING Mengmeng;XIE Li;LI Yong’an(Department of Neurology,Xiangcheng People's Hospital of Suzhou City,Suzhou 215000,China;不详)
出处
《中国医学创新》
2026年第2期140-144,共5页
Medical Innovation of China
关键词
急性脑梗死
依达拉奉右莰醇
康复模式
吞咽能力
神经功能
Acute cerebral infarction
Edaravone and Dexborneol
Rehabilitation model
Swallowing ability
Neurological function
