摘要
目的:探究跨膜蛋白206(TMEM206)在甲状腺癌(TC)中的表达及预后价值。方法:采用标准化平均差结合随机效应模型分析多中心样本TC与非癌甲状腺组织中TMEM206的表达差异,并运用卡普兰-迈耶法评估其预后价值。结果:TMEM206 mRNA在TC组织相较于非癌甲状腺组织表达升高(SMD=0.42,95%CI:0.08-0.77),Egger和Begg检验未发现明显偏倚(P>0.05),通过受试者工作特征曲线评估TMEM206 mRNA的表达特征,其灵敏度为0.57(95%CI:0.39-0.74),特异度为0.84(95%CI:0.58-0.95)。阳性似然比为3.57(95%CI:1.36-9.38),阴性似然比为0.51(95%CI:0.36-0.72)。在蛋白水平上,TC组织的TMEM206表达量较非癌组织显著增加(P<0.05)。TMEM206是TC患者的危险因素无统计学意义(P>0.05)。结论:TMEM206在TC中呈现显著高表达,提示其可能参与TC的病理进程,未来需通过功能实验明确其分子机制。
Objective:To investigate the expression and prognostic value of transmembrane protein 206(TMEM206)in thyroid cancer(TC).Methods:Standardized mean difference combined with random effect model was used to analyze the difference of TMEM206 expression between TC and non-cancerous thyroid tissues in multi-center samples,and Kaplan-Meier method was used to evaluate its prognostic value.Results:The expression of TMEM206 mrna in TC tissues was higher than that in non-cancerous thyroid tissues(SMD=0.42,95%CI:0.08-0.77),and Egger and Begg tests showed no significant bias(P>0.05).The expression characteristics of TMEM206 mrna were evaluated by receiver operating characteristic curve,with a sensitivity of 0.57(95%CI:0.39-0.74)and a specificity of 0.84(95%CI:0.58-0.95),the positive likelihood ratio was 3.57(95%CI:1.36-9.38),and the negative likelihood ratio was 0.51(95%CI:0.36-0.72).At the protein level,the expression of TMEM206 in TC tissues was significantly higher than that in non-cancerous tissues(P<0.05).Conclusion:TMEM206 is highly expressed in TC,suggesting that it may be involved in the pathological process of TC,and its molecular mechanism needs to be clarified through functional experiments in the future.
作者
覃凯
莫军扬
覃舒婷
宋畅
屈宁
陈罡
庞玉艳
QIN Kai;MO Junyang;QIN Shuting;SONG Chang;QU Ning;CHEN Gang;PANG Yuyan(Department of Pathology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Breast and Thyroid Surgery,Liuzhou People′s Hospital)
出处
《包头医学院学报》
2025年第12期51-55,共5页
Journal of Baotou Medical College
基金
广西壮族自治区卫生健康委员会科研课题(Z-A20220521)
大学生创新创业训练计划项目(202310598042)。
关键词
跨膜蛋白206
甲状腺癌
标准化平均差
蛋白表达
预后价值
Transmembrane protein 206
Thyroid cancer
Standardized mean difference
Protein expression
Prognostic value
