摘要
非HACEK革兰阴性菌感染性心内膜炎是一种罕见但日益受到重视的疾病,具有高发病率和高死亡率的特点。铜绿假单胞菌、粘质沙雷氏菌、肺炎克雷伯杆菌和大肠埃希菌是主要病原体。本文报道1例血培养阴性的心内膜炎患者,通过宏基因组二代测序(mNGS)明确感染病原体为产KPC、NDM肺炎克雷伯杆菌,通过精准的抗感染治疗,感染指标明显下降。
Non-HACEK Gram-negative bacterial endocarditis is a rare but increasingly recognized disease,characterized by high morbidity and mortality.Pseudomonas aeruginosa,Serratia marcescens,Klebsiella pneumoniae,and Escherichia coli are recognized as the main pathogens.This article reports a case of endocarditis with negative blood culture.Patient’s pathogen was identified as KPC and NDM-producing Klebsiella pneumoniae through metagenomic next-generation sequencing(mNGS).Through precise anti-infection treatments,the infection indicators decreased significantly.
作者
赵国敏
刘平
赵晓宁
张辉
李宏亮
ZHAO Guomin;LIU Ping;ZHAO Xiaoning;ZHANG Hui;LI Hongliang(Department of Critical Care Medicine,Center for Critical Care Medicine,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Ultrasound,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)
出处
《标记免疫分析与临床》
2026年第1期220-223,共4页
Labeled Immunoassays and Clinical Medicine
基金
2022年度北京市重大疫情防治重点专科建设类项目(编号:ZDYQFZZDZK)。
关键词
肺炎克雷伯杆菌
感染性心内膜炎
宏基因组二代测序
Klebsiella pneumoniae
Infective endocarditis
Metagenomic next-generation sequencing
