摘要
维生素D(vitamin D,VD)作为一种具有多重生物学效应的类固醇激素,近年来在免疫调节和表观遗传调控中的关键作用逐渐被揭示。研究表明,VD通过其核受体(维生素D受体,VDR)介导的信号通路,直接或者间接影响甲状腺自身抗体(如TPOAb、TRAb)的产生。VD缺乏可导致VDR功能障碍,引发Th17/Treg免疫失衡及B细胞异常活化,并与促甲状腺素受体(TSHR)基因低甲基化、miR-155过表达等表观遗传异常密切相关,共同推动自身免疫性甲状腺疾病(AITD)的发生发展。临床研究证实,补充VD可显著改善甲状腺自身抗体水平及免疫状态,为AITD的辅助治疗提供了理论依据。未来研究需进一步明确VD补充的剂量-效应关系,并探索基于VDR基因多态性的个体化治疗策略。
Vitamin D,a steroid hormone with pleiotropic biological effects,has been increasingly recognized for its crucial roles in immune regulation and epigenetic modulation.Previous evidence indicates that VD,primarily through signaling pathways mediated by its nuclear receptor(VDR),directly or indirectly influences the production of thyroid autoantibodies(e.g.,TPOAb,TRAb).Vitamin D deficiency can lead to VDR dysfunction,triggering an imbalance between Th17 and Treg cells and abnormal activation of B cells.It is also closely associated with epigenetic abnormalities,such as hypomethylation of the thyroid-stimulating hormone receptor(TSHR)gene and overexpression of miR-155,collectively driving the onset and progression of autoimmune thyroid diseases(AITD).Multiple clinical studies have confirmed that VD supplementation significantly improves thyroid autoantibody levels and immune status,providing a theoretical basis for adjuvant therapy in AITD.Suggested by knowledge gained,future research should focus on elucidating the dose-response relationship of VD supplementation and developing personalized treatment strategies based on VDR gene polymorphisms.
作者
袁飞燕
葛静
YUAN Feiyan;GE Jing(Nanjing University of Chinese Medicine,Nanjing 210029,China;Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《标记免疫分析与临床》
2026年第1期196-200,共5页
Labeled Immunoassays and Clinical Medicine
基金
江苏省中医药局科技项目(编号:LZ13060)。
