摘要
目的观察解毒化瘀汤治疗溃疡性结肠炎(UC)(大肠湿热证)活动期患者临床疗效及对外周血树突状细胞(DCs)表型的影响。方法70例患者随机分为对照组与观察组各35例。对照组给予美沙拉秦肠溶片治疗,观察组在对照组的基础上给予解毒化瘀汤口服治疗,两组疗程均为3周。观察两组患者治疗前后中医证候积分、炎症性肠病生存质量问卷评分、Mayo内镜评分、Sutherland疾病活动指数、外周血树突状细胞表型,评估临床疗效。结果观察组总有效率为94.29%,高于对照组的85.71%(P<0.05)。两组治疗后中医证候积分、Mayo内镜评分、Sutherland疾病活动指数、外周血树突状细胞MHC-Ⅱ、CD80和CD86的频率较治疗前均显著降低(P<0.05),炎症性肠病生存质量问卷评分显著升高(P<0.05),观察组均优于对照组(P<0.05)。结论解毒化瘀汤治疗UC(大肠湿热证)活动期患者可能通过抑制DCs成熟分化,从而减轻临床症状,提高生存质量,降低疾病活动度。
Objective:To observe the clinical efficacy of Jiedu Huayu Decoction and its effect on the phenotype of peripheral blood dendritic cells(DCs)in patients with active ulcerative colitis(UC)of syndrome of dampnessheat in large intestine.Methods:A total of 70 patients with active UC were randomly divided into the control group and the observation group,with 35 cases in each group.The control group was treated with mesalazine enteric-coated tablets,while the observation group was additionally given oral Jiedu Huayu Decoction on the basis of the control group's treatment.The course of treatment for both groups was 3 weeks.The changes in TCM syndrome scores,inflammatory bowel disease questionnaire(IBDQ)scores,Mayo endoscopic scores,Sutherland disease activity index,and the phenotype of peripheral blood DCs were observed before and after treatment in both groups to evaluate clinical efficacy.Results:The clinical effective rate of the observative group was 94.29%,which was higher than 85.71%of the control group(P<0.05).After treatment,the TCM syndrome scores,Mayo endoscopic scores,Sutherland disease activity index,and the frequencies of MHC-I,CD80 and CD86 in peripheral blood DCs were significantly decreased in both groups(P<0.05),while the IBDQ scores were significantly increased(P<0.05),and the observation group were all superior to those in the control group,with statistically significant differences(P<O.05).Conclusion:Jiedu Huayu Decoction in the treatment of patients with active UC and syndrome of dampness-heat in large intestine may alleviate clinical symptoms,improve quality of life,and reduce disease activity by inhibiting the maturation and differentiation of DCs.
作者
李丽萍
袁星星
李婧
Li Liping;Yuan Xingxing;Li Jing(Heilongjiang Academy of Chinese Medical Sciences,Heilongjiang,Harbin 150006,China)
出处
《中国中医急症》
2026年第2期182-185,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
中华中医药学会青年培英计划(202557-011)。
关键词
溃疡性结肠炎
大肠湿热证
解毒化瘀汤
树突状细胞
临床疗效
Ulcerative colitis
Syndrome of dampness-heat in large intestine
Jiedu Huayu Decoction
Dendritic cells
Clinical efficacy
