摘要
炎症是机体应对损伤、感染或其他刺激的应答反应,但其过度或持续发展会导致多种疾病。现代医学抗炎疗法虽应用广泛,却常伴随不良反应较多等局限性。中医药基于“整体观”与“辨证论治”,将炎症视为机体阴阳失衡、正邪交争的表现。抗炎中药的应用不仅仅针对“炎症”这一病理状态,更是基于对“证候”的整体考量。根据不同的证候类型,抗炎中药可分为清热解毒类(如金银花、大青叶)、清热燥湿类(如黄连)、活血化瘀类(如丹参)以及扶正祛邪类(如人参)。4类抗炎中药通过多成分、多靶点、多通路的系统调节来恢复机体免疫平衡,呈现出良好的抗炎效应。未来研究应聚焦于融合系统生物学、运用人工智能、开展高质量循证研究以及中西药联用等,以揭示中药抗炎的整体调控规律,促进临床合理用药。
Inflammation is the body’s response to damage,infection or other stimuli,but its excessive or continuous development can lead to a variety of diseases.Although modern medical anti-inflammatory therapies were widely used,it is often accompanied by limitations such as more adverse reactions.Based on the“holistic view”and“differential treatment”,traditional Chinese medicine(TCM)regards inflammation as a manifestation of the imbalance of yin and yang in the body and the conflict between good and evil.The application of anti-inflammatory TCM is not only aimed at the pathological state of“inflammation”,but also based on the overall consideration of“syndrome”.According to different types of syndrome,anti-inflammatory TCM can be divided into heat-clearing and detoxifying agents(such as Lonicera japonica and Isatis indigotica),heat-clearing and drying dampness agents(such as Coptidis Rhizoma),blood-activating and stasis-dissolving agents(such as Salvia miltiorrhiza)and vital qi-strengthening and pathogenic factor-expelling agents(such as Panax ginseng).Four types of anti-inflammatory TCM restore the body’s immune balance through the systematic regulation of multi-component,multi-target and multi-pathway,exhibiting a good anti-inflammatory effect.Future research should focus on integrating systematic biology,applying artificial intelligence,carrying out high-quality evidence-based research,and combining traditional Chinese medicine and Western medicine,so as to reveal the overall regulatory law of anti-inflammatory effects of TCM and promote clinical rational use.
作者
包嘉宁
张晓楠
陶旭锋
项红
董得时
BAO Jianing;ZHANG Xiaonan;TAO Xufeng;XIANG Hong;DONG Deshi(Dept.of Pharmacy,The First Affiliated Hospital of Dalian Medical University,Liaoning Dalian 116011,China;College of Pharmacy,Dalian Medical University,Liaoning Dalian 116044,China;College of Integrative Medicine,Dalian Medical University,Liaoning Dalian 116044,China)
出处
《中国药房》
北大核心
2026年第4期528-532,共5页
China Pharmacy
基金
国家自然科学基金项目(No.82200713)
大连市科技创新基金项目(No.2024JJ12PT013)。
关键词
炎症
中药
辨证论治
清热解毒
inflammation
traditional Chinese medicine
syndrome differentiation and treatment
drug for heat-clearing and detoxifying
