摘要
目的:探讨血清胱抑素C(Cys-C)和视黄醇结合蛋白(RBP)联合尿微量白蛋白/肌酐比值(ACR)与2型糖尿病肾病(T2DN)患者病变程度的关系。方法:纳入103例T2DN患者作为T2DN组,根据糖尿病肾病患者尿白蛋白排泄率,将其分为T2DN早期组(n=36)、临床期组(n=55)、尿毒症组(n=12);同时选择同一时间的105例单纯2型糖尿病(T2DM)患者作为T2DM组。检测并比较T2DN组和T2DM组患者血清Cys-C、RBP、ACR,并分析其与疾病严重程度的关系;采用ROC曲线分析Cys-C、RBP、ACR及三者联合对T2DN疾病严重程度的诊断效能。结果:T2DN组患者血清Cys-C、RBP、ACR水平均高于T2DM组(P<0.05);T2DN临床期组及尿毒症组患者Cys-C、RBP、ACR水平均高于早期组(P<0.05),Cys-C、RBP、ACR与疾病严重程度均呈正相关关系(P<0.05);Cys-C、RBP、ACR联合诊断T2DN临床期及尿毒症期的曲线下面积(AUC)为0.934,高于三者单独诊断(P<0.05)。结论:Cys-C、RBP、ACR的变化与T2DN患者病变程度正相关,且三者联合诊断T2DN效能较高。
Objective:To explore the relationship between serum cystatin C(Cys-C),retinol binding protein(RBP),urine microalbumin to creatinine ratio(ACR)and disease severity in patients with type 2 diabetic nephropathy(T2DN).Methods:A total of 103 patients with T2DN were enrolled as T2DN group.According to excretion rate of urinary albumin,they were divided into early stage group(n=36),clinical stage group(n=55)and uremia group(n=12).A total of 105 patients with type 2 diabetes mellitus(T2DM)during the same period were enrolled as T2DM group.The levels of serum Cys-C,RBP and ACR in T2DN group and T2DM group were detected and compared,and their relationship with disease severity was analyzed.The diagnostic efficiency of Cys-C,RBP,ACR and combined detection for the severity of T2DN was analyzed by ROC curves.Results:The levels of serum Cys-C,RBP and ACR in T2DN group were higher than those in T2DM group(P<0.05).The levels of Cys-C,RBP and ACR in clinical stage group and uremia group were higher than those in early stage group(P<0.05).Serum Cys-C,RBP and ACR were positively correlated with disease severity(P<0.05).AUC of Cys-C combined with RBP and ACR in the diagnosis of T2DN in clinical stage and uremia stage was 0.934,greater than that of single index(P<0.05).Conclusion:The changes of Cys-C,RBP and ACR are positively correlated with the severity of T2DN,and combined detection of the three indexes has higher diagnostic efficiency.
作者
唐曦
吕彬
黄俊
TANG Xi;LV Bin;HUANG Jun(Department of Nephrology,Chengdu Sixth People s Hospital,Chengdu 610051,Sichuan,China)
出处
《川北医学院学报》
2026年第2期249-251,256,共4页
Journal of North Sichuan Medical College
关键词
胱抑素
视黄醇结合蛋白
尿微量蛋白
肌酐
糖尿病肾病
Cystatin
Retinol-binding protein
Urine microalbumin
Creatinine
Diabetic nephropathy
