摘要
目的本研究旨在探究磁压榨技术(MCT)应用于兔模型中输尿管中段单处严重狭窄治疗的可行性。方法选取10只雌性新西兰兔,对其右侧输尿管远端进行丝线结扎。术后2周待右侧输尿管扩张后,于扩张的输尿管中段再次实施丝线结扎,以制备输尿管单处严重狭窄动物模型。纵行切开输尿管结扎处的上下端,分别置入中心带孔的圆柱形钕铁硼(NdFeB)磁体(子磁体和母磁体)进行输尿管中段狭窄的吻合再通。将子母磁体调整至合适位置,使其自动对位吸合,使用6-0 Prolene线缝合输尿管纵行切开部位,之后逐层关闭腹腔,记录手术时间。磁压榨吻合术术后每2天拍摄1次X光片,以确认磁体的位置,记录磁体脱落时间。术后3周,获取吻合口标本,通过肉眼观察和组织学染色,评估吻合口的形成情况。结果结扎2周后,所有实验兔右侧输尿管均呈现明显扩张状态,10只实验兔顺利完成中段输尿管结扎以及子母磁体的置入操作,手术操作时间为(24.00±5.15)min。母磁体与子磁体相互吸引效果良好,X线检查显示磁压榨吻合术术后(14.0±1.9)d子母磁体脱落并进入输尿管远端,成功实现了输尿管单处严重狭窄的再通。大体标本和吻合口组织学检查结果表明吻合口保持通畅、黏膜愈合状况良好。所有实验兔在术后均存活状态良好,未出现严重并发症。结论MCT为输尿管中段狭窄的治疗提供了一种新的思路和方法,在兔模型中证实了该技术治疗输尿管单处严重狭窄的可行性,且操作相对简单,具有一定的临床应用潜力。
Objective To explore the feasibility of magnetic compression technique(MCR)in the treatment of severe single mid-ureteral stricture in a rabbit model.Methods After 10 female New Zealand rabbits were selected,the distal end of the right ureter was ligated with silk thread.Two weeks after the operation,when the right ureter was dilated,the mid-ureter was ligated again with silk thread to create a severe single mid-ureteral stricture animal model.Longitudinal incisions were made at the upper and lower ends of the ligation site,and cylindrical NdFeB magnets with central holes(sub-magnets and main magnets)were placed to anastomose and recanalize the mid-ureteral stricture.The magnets were adjusted to the appropriate position to automatically align and attract each other.The longitudinal incision sites of the ureter were sutured with 6-0 Prolene thread,and the abdominal cavity was closed layer by layer.The operation time was recorded.X-ray films were taken every two days to confirm the position of the magnets and record the time of magnet detachment.Three weeks after the operation,the anastomotic specimens were obtained,and the formation of the anastomosis was evaluated with gross observation and histological staining.Results Two weeks after ligation,all experimental rabbits showed obvious dilation of the right ureter.The mid-ureteral ligation and placement of the male and female magnets were successfully completed in all 10 experimental rabbits,with an operation time of(24.00±5.15)minutes.The male and female magnets attracted each other well.X-ray examination showed that the magnets detached and entered the distal ureter(14.0±1.9)days after magnetic compression.The recanalization of the severe single mid-ureteral stricture was successfully achieved.The gross specimens and histological examination of the anastomosis showed that the anastomosis remained patent and the mucosal healing was good.All experimental rabbits survived well after the operation without serious complications.Conclusion MCT provides a new idea and novel method for the treatment of mid-ureteral stricture.This study confirmed the feasibility of this technique in treating severe single mid-ureteral stricture in a rabbit model.The operation is relatively simple and has potential for clinical application.
作者
魏凡超
王照翔
韩士超
董治文
付雨心
戚若晨
王国辉
张小燕
徐桐
张景良
秦卫军
杨力军
马帅军
WEI Fanchao;WANG Zhaoxiang;HAN Shichao;DONG Zhiwen;FU Yuxin;QI Ruochen;WANG Guohui;ZHANG Xiaoyan;XU Tong;ZHANG Jingliang;QIN Weijun;YANG Lijun;MA Shuaijun(Department of Urology,Xijing Hospital of Air Force Medical University,Xi'an 710032,China)
出处
《现代泌尿外科杂志》
2026年第2期182-186,共5页
Journal of Modern Urology
关键词
磁压榨技术
输尿管中段狭窄
动物实验
磁外科
磁吻合
magnetic compression technique
mid-ureteral stricture
animal experiment
magnetic surgery
magnetic anastomosis
