摘要
目的:探究人免疫球蛋白结合甲泼尼龙冲击疗法对急性期多发性硬化患者的影响。方法:选定2023年2月—2025年2月广安市中医医院收治的急性期多发性硬化患者120例为研究对象,根据随机数字表法分为两组。对照组(60例)行甲泼尼龙冲击疗法,研究组(60例)在对照组基础上给予人免疫球蛋白治疗。对比组间免疫学指标、神经系统功能、治疗效果及不良反应发生率。结果:治疗后,研究组白细胞计数、白细胞介素-6、干扰素-γ水平较对照组低(P<0.001);治疗后,研究组扩展残疾状态量表评分较对照组低(P<0.001);研究组总有效率较对照组高(P=0.008);两组不良反应总发生率对比,无统计学差异(P>0.05)。结论:在甲泼尼龙冲击疗法基础上,为急性期多发性硬化患者提供人免疫球蛋白治疗的效果更为确切,可改善其免疫学指标,减轻神经功能缺损程度,且未增加不良反应,临床应用价值较高。
Objective:To explore the effect of human immunoglobulin combined with methylprednisolone pulse therapy on patients with acute multiple sclerosis.Methods:A total of one hundred and twenty patients with acute multiple sclerosis who were admitted to Guang'an Hospital of Traditional Chinese Medicine from February 2023 to February 2025 were selected as the research subjects.They were divided into two groups according to the random number table method.The control group(60 cases)received methylprednisolone pulse therapy,while the study group(60 cases)was treated with human immunoglobulin in addition to the therapy of the control group.The immunological indicators,neurological functions,treatment effects and incidence of adverse reactions among different groups were compared.Results:After treatment,the white blood cell count,interleukin-6 and interferon-γlevels in the study group were lower than those in the control group(P<0.001).After the treatment,the score of the expanded disability status scale in the study group was lower than that in the control group(P<0.001).The overall effective rate of the study group was higher than that of the control group(P=0.008).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Based on the methylprednisolone pulse therapy,providing human immunoglobulin treatment for patients with acute multiple sclerosis has a more definite effect.It can improve their immunological indicators,reduce the degree of neurological dysfunction,and does not increase adverse reactions.Therefore,its clinical application value is relatively high.
作者
苏滑
李正敏
范东
Su Hua;Li Zhengmin;Fan Dong(Department of Neurology,Guang'an Hospital of Traditional Chinese Medicine,Guang'an 638500,Sichuan Province,China)
出处
《中外医药研究》
2025年第36期37-39,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
