摘要
目的通过文献计量分析和可视化技术,明确纳米材料在脑胶质瘤治疗中的应用现状、研究热点及趋势,为该领域未来的研究方向提供科学依据。方法本研究基于Web of Science核心合集数据库,检索2013年7月1日—2025年7月1收录的纳米材料与脑胶质瘤相关英文文献。运用VOSviewer和CiteSpace软件,对纳入文献的发表年份、国家和区域分布、作者、期刊、机构、关键词等进行计量分析和可视化展示。结果共检索到6270篇关于纳米材料介导脑胶质瘤的英文文章,包括1013篇Review和5257篇Article。2013—2025年间,纳米材料治疗脑胶质瘤领域的发文量总体呈上升趋势,全球共有105个国家参与该领域研究,中国和美国贡献最突出,发文量位居第1和第2。在作者中,Gao Huile发文量和被引频次均居榜首。文献分布在978种期刊中,Journal of Controlled Release发文最多。5450个研究机构中,中国科学院和复旦大学表现突出。研究热点集中于纳米材料跨越血脑屏障与靶向递药系统、光动力和光热治疗,以及临床转化中的挑战与安全性问题。结论纳米材料在脑胶质瘤治疗中显示出重要的应用价值和前景,尤其在增强药物靶向性与开发新型治疗策略方面。未来需进一步推动材料优化与临床转化研究,解决生物安全性与规模化制备等关键问题。
Objective Through bibliometric analysis and visualization techniques,to clarify the current application status,research hotspots,and trends of nanomaterials in the treatment of gliomas,and to provide a scientific basis for future research directions in this field.Methods This study wason based the Web of Science Core Collection database to retrieve literature related to nanonmaterials and glioma and reviews published between July 1,2013,and July 1,2025.The quantitative analysis and visualization of the included literature were conducted using VOSviewer and CiteSpace software to examine publication years,country and regional distribution,authors,journals,institutions,keywords,and other factors.Results A total of 6270 English articles on nanomaterialsmediated gliomas were retrieved,including 1013 reviews and 5257 articles.From 2013 to 2025,the overall number of publications in the field of nanomaterial therapy for glioma showed an overall upward trend.A total of 105 countries worldwide participated in research in this field,with China and the United States making the most prominent contributions,ranking first and second in publication volume.Among authors,Gao Huile topped both publication volume and citation frequency.Publications were distributed across 978 journals,with the Journal of Controlled Release publishing the highest number of articles.Among 5,450 research institutions,the Chinese Academy of Sciences and Fudan University demonstrated outstanding performance.Research hotspots centered on nanomaterials crossing the blood-brain barrier and targeted drug delivery systems,photodynamic and photothermal therapies,as well as challenges and safety concerns in clinical translation.Conclusion Nanomaterials demonstrate significant application value and promise in glioma treatment,particularly in enhancing drug targeting and developing novel therapeutic strategies.Future efforts should focus on advancing material optimization and clinical translation research to address critical challenges such as biosafety and large-scale production.
作者
蒋岚芳
郭思彤
黄可
许丹丹
许启猛
陈晓宇
JIANG Lanfang;GUO Sitong;HUANG Ke;XU Dandan;XU Qimeng;CHEN Xiaoyu(Graduate School of Guangxi University of Chinese Medicine,Nanning 530000,China;Department of Pharmacy,The Peoples Hospital of Guangxi Zhuang Autonomous Region,Nanning 530000,China)
出处
《药学前沿》
2026年第1期116-127,共12页
China Pharmacist
