摘要
化脓性汗腺炎(HS)是一种复杂的慢性炎症性皮肤疾病,典型临床特征包括疼痛性脓肿、深部结节、瘘管和瘢痕形成,主要发生在腋窝和腹股沟等皮肤褶皱部位。HS的发病机制尚未完全阐明,临床治疗棘手。近年多项研究表明皮肤与肠道微生物组失调在HS发病过程中起关键作用,HS患者的皮肤与肠道微生物组均呈现多样性下降与病原菌增多的特征,此类微生物失调可能通过激活宿主免疫反应加剧炎症,并可能形成持续的炎症正反馈回路,推动疾病慢性化。通过靶向微生物组的干预(如益生菌补充)恢复肠道菌群平衡,有望打破HS炎症循环,成为潜在的治疗方向。然而微生物组的具体作用机制仍存疑问,未来需深化研究,包括开发靶向治疗方法(如基于肠-皮轴的双向调控)和标准化微生物组分析以促进HS治疗的精准化。该文对皮肤及肠道微生物在HS发病机制中的潜在作用研究进展进行综述,以期为临床探索HS治疗策略提供新思路。
Hidradenitis Suppurativa(HS)is a complex chronic inflammatory skin disease,its characterized clinical symptoms include painful abscesses,deep nodules,fistulas and scar formation,it mainly affects the skin folds such as the armpits and groin.The pathogenesis of HS has not been fully elucidated,and its clinical treatment is tricky.Recent studies have demonstrated that dysbiosis of the skin and gut microbiome plays a pivotal role in the pathogenesis of HS.The skin and intestinal microbiome of HS patients both show the characteristics of decreased diversity and increased pathogenic bacteria.HS patients exhibit the reduced microbial diversity and increased pathogenic bacteria in both skin and gut microbiomes.This microbial imbalance may exacerbate the inflammatory responses by activating host immune reactions,may form a continuous positive feedback loop of inflammation and promote the disease chronicity.Interventions targeting the microbiome such as probiotic supplementation restore the balance of the intestinal flora and thereby breaking the inflammatory cycle of HS,have become potential therapeutic directions.However,the specific mechanism of microbiome action remains questionable.In the future,further research is needed,including the development of targeted therapeutic methods(such as bidirectional regulation based on the gut-skin axis)and standardized microbiome analysis to promote the precision of HS treatment.This article reviews the progress of the potential role of skin and intestinal microbiota in the pathogenesis of HS in order to provide the new ideas for the clinical exploration of HS treatment strategies.
作者
陈雪琴
陈晨
翟志芳(综述)
胡建军(审校)
CHEN Xueqin;CHEN Chen;ZHAI Zhifang;HU Jianjun(Department of Dermatology,First Affiliated Hospital,Army Military Medical University,Chongqing 400038,China;College of Animal Husbandry and Veterinary,Southwest Nationality University,Chengdu,Sichuan 610041,China;Department of Oncology,First Affiliated Hospital,Army Military Medical University,Chongqing 400038,China)
出处
《检验医学与临床》
2026年第4期564-569,576,共7页
Laboratory Medicine and Clinic
基金
国家自然科学基金项目(82202035)
中国博士后科学基金项目(2023M734258)
重庆市自然科学基金项目(CSTB2022NSCQMSX0210)。
关键词
化脓性汗腺炎
皮肤微生物
肠道微生物
肠-皮轴
治疗
hidradenitis suppurativa
skin microbiome
gut microbiome
gut-skin axis
treatment
