摘要
目的:探讨孕激素联合宫腔镜手术治疗子宫内膜息肉的疗效以及对术后复发的影响。方法:回顾性分析2021年1月—2023年1月信阳市中心医院收治的75例子宫内膜息肉患者的临床资料,根据不同治疗方式将其分为观察组(38例)和对照组(37例)。对照组采用宫腔镜手术治疗,观察组采用宫腔镜手术联合孕激素治疗。比较两组患者术前和术后6个月时的月经量、子宫内膜厚度、孕激素受体、雌激素受体、生殖内分泌激素[血清黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)]水平以及术后6个月内的复发情况。结果:术后6个月,观察组患者子宫内膜厚度、月经失血图(PBAC)评分、雌激素受体、FSH、E_(2)、LH均低于对照组,孕激素受体、复发率均高于对照组,差异均有统计学意义(P<0.05)。结论:宫腔镜手术联合孕激素治疗子宫内膜息肉疗效显著,可降低患者术后月经量,调节孕激素受体、雌激素受体、生殖内分泌激素水平,改善子宫内膜厚度,减少术后复发。
Objective:To explore the efficacy of progesterone combined with hysteroscopic surgery in the treatment of endometrial polyps and its impact on postoperative recurrence.Methods:A retrospective analysis of clinical data from 75 patients with endometrial polyps admitted to Xinyang Central Hospital between January 2021 and January 2023 was conducted.Based on different treatment modalities,patients were divided into an observation group(38 cases)and a control group(37 cases).The control group underwent hysteroscopic surgery alone,while the observation group received hysteroscopic surgery combined with progestin therapy.The levels of menstrual flow(PBAC)score,endometrial thickness,progesterone receptor,estrogen receptor,reproductive endocrine hormones including luteinizing hormone(LH),follicle stimulating hormone(FSH),and estradiol(E_(2))before and 6 months after surgery between the two groups,as well as the recurrence rate within 6 months after surgery were compared.Results:At 6 months postoperatively,patients in the observation group exhibited significantly lower endometrial thickness,PBAC scores,estrogen receptor levels,FSH,E_(2),and LH compared to the control group,while showing significantly higher progesterone receptor levels and recurrence rates,with all differences statistically significant(P<0.05).Conclusion:Hysteroscopic surgery combined with progestin therapy demonstrates significant efficacy in treating endometrial polyps.This approach reduces postoperative menstrual flow,regulates progesterone receptor,estrogen receptor,and reproductive endocrine hormone levels,improves endometrial thickness,and decreases postoperative recurrence.
作者
陆平
郑洁
陈东思
李玉梅
Lu Ping;Zheng Jie;Chen Dongsi(Department of Obstetrics and Gynecology,Xinyang Central Hospital,Xinyang,Henan,464000,China)
出处
《黑龙江医学》
2026年第2期178-180,共3页
Heilongjiang Medical Journal
关键词
子宫内膜息肉
孕激素
宫腔镜手术
复发
Endometrial polyps
Progesterone
Hysteroscopic surgery
Recurrence
