摘要
v-ets红母细胞病病毒E26原癌基因同源物2(v-ets erythroblastosis virus E26 oncogene homolog 2,ETS2)是一种转录因子,它广泛参与机体生长、发育等正常生理功能的调节以及肿瘤的发生。此外,ETS2的表达和活性异常也与心血管疾病的发生发展有着密切的关系。本文将对ETS2在心血管疾病研究领域中的最新进展进行综述,为今后探索心血管疾病的发生机制和开发治疗靶点提供新思路。
v-ets erythroblastosis virus E26 oncogene homolog 2(ETS2)is a transcription factor that plays a crucial role in regulating normal physiological processes such as growth and development,as well as in tumorigenesis.Moreover,aberrant expression and activity of ETS2 are closely associated with the pathogenesis and progression of cardiovascular diseases.This review summarizes the latest advances in ETS2 research within the context of cardiovascular diseases,providing new insights for future investigations into the pathogenesis of cardiovascular diseases and the development of therapeutic targets.
作者
李海兵
丛馨
LI Hai-Bing;CONG Xin(Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Peking University,Beijing 100191,China)
出处
《生理科学进展》
北大核心
2026年第1期79-87,共9页
Progress in Physiological Sciences
基金
国家自然科学基金(31972908)资助课题。
关键词
心血管发育
心血管疾病
转录因子
ETS2
cardiovascular development
cardiovascular disease
transcription factor
ETS2
