摘要
目的膝骨关节炎(KOA)是我国中老年人群中常见的慢性退行性疾病,严重影响患者的生活质量和工作能力。目前所使用的非甾体抗炎药、糖皮质激素及手术等治疗手段存在药物不良反应风险及患者接受度较低等问题。中医药在KOA治疗中具有独特优势,淫羊藿是治疗KOA方剂中的高频药物,其主要有效成分包括淫羊藿苷、淫羊藿总黄酮、山柰酚、槲皮素等;这些成分通过调节Wnt/β-catenin、NF-κB、Nrf2/HO-1等信号通路,发挥促进软骨细胞外基质合成、抑制细胞凋亡、抑制炎性因子水平、促进细胞自噬的作用,最终延缓KOA的病情进展。该文通过对淫羊藿及其有效成分在治疗KOA方面的作用机制进行综述,为KOA的治疗以及新药研发提供方向和依据。
Knee osteoarthritis(KOA)is a common chronic degenerative disease among middle-aged and elderly people in China,which seriously affects their life and work.The current treatment methods used,such as nonsteroidal anti-inflammatory drugs,glucocorticoids,and surgery,have the risk of adverse drug reactions and low patient acceptance.The advantages of tradi tional Chinese medicine in treating KOA are becoming increasingly prominent.Epimedium,as a frequently used medication in traditional Chinese medicine formulas for treating KOA,is mainly composed of active ingredients such as icariin,total flavonoids of Epimedium,kaempferol,and quercetin in the field of KOA treatment;These components regulate signaling pathways such as Wnt/β-catenin,NF-κB,Nrf2/HO-1,and play a role in promoting chondrocyte extracellular matrix synthesis,inhibiting cell apoptosis,suppressing inflammatory cytokine levels,and promoting autophagy,ultimately achieving the goal of delaying the progression of KOA.This article reviews the mechanism of action of Epimedium and its active ingredients in the treatment of KOA,providing direction and basis for the treatment of KOA and the development of new drugs.
作者
白家奇
张宇
郑曲
陈巍
宫云昭
BAI Jiaqi;ZHANG Yu;ZHENG Qu;CHEN Wei;GONG Yunzhao(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China)
出处
《实用中医内科杂志》
2026年第2期115-119,共5页
Journal of Practical Traditional Chinese Internal Medicine
基金
辽宁省科技计划联合计划(基金)项目(2023-MSLH-143)
辽宁省教育厅高校基本科研项目(面上项目)(LJKMZ20221327)
辽宁省创新能力提升联合基金(2022-NLTS-13-02)。
关键词
淫羊藿
有效成分
膝骨关节炎
信号通路
作用机制
槲皮素
Epimedium
Active ingredient
Knee osteoarthritis
Signaling pathway
Mechanism of action
Quercetin
