摘要
自噬,又称为细胞的自我吞噬,与多种疾病的发生发展存在密切关联。融合突触蛋白17(Syntaxin17,STX17)在自噬调节中起着重要作用,STX17与ATG14、Pacer、MAP1B-LC1、PI4P结合介导自噬体形成,与SNARE复合物、HOPS复合物、ATG8、RAB蛋白结合调控自噬体与溶酶体间的膜融合过程。STX17磷酸化调节Omega小体和后期复合物的形成、乙酰化调节膜融合过程、泛素化调控其降解。这些机制虽被广泛研究,但尚未全面系统性地整理分析,该文对STX17在自噬中的作用机制、翻译后修饰对自噬的影响及其在各种疾病中的作用机制进行综述,以期为STX17相关自噬靶向药物研究提供参考。
Autophagy,also known as self phagocytosis of cells,is strongly associated with the development of many diseases.Syntaxin17(STX17)plays an important role in the regulation of autophagy.STX17 binds to ATG14,Pacer,MAP1B-LC1,and PI4P to mediate the formation of autophagosomes,and binds to SNARE complex,HOPS complex,ATG8,and RAB proteins to regulate the membrane fusion process between autophagosomes and lysosomes.STX17 phosphorylation regulates the formation of omega vesicles and late complexes,acetylation regulates the membrane fusion process,and ubiquitination regulates their degradation.Although these mechanisms have been widely studied,a systematic compilation and analysis is still lacking.In this paper,we review the mechanism of STX17 in autophagy,the effect of post translational modifications on autophagy and its mechanism of action in a variety of diseases,with the aim of providing a reference for the study of STX17 related autophagy-targeting drugs.
作者
黄惠利
任艳起
HUANG Huili;REN Yanqi(School of Life and Health Sciences,Hubei University of Technology,Wuhan 430068;Hebi Women and Children's Healthcare Hospital,Hebi 458000,China)
出处
《生物技术》
2025年第6期798-804,共7页
Biotechnology
关键词
STX17
SNARE复合物
自噬
翻译后修饰
磷酸化
乙酰化
泛素化
疾病
STX17
SNARE complex
autophagy
post translational modification
phosphorylation
acetylation
ubiquitination
disease
