摘要
In recent years the crucial role of CD4^(+)T cells in tumor immunomodulation has garnered increasing recognition.While conventional cancer immunotherapy research has predominantly focused on the cytotoxic function of CD8+T cells,emerging evidence has now shown that CD4^(+)T cells enhance antitumor immunity by delivering co-stimulatory signals,secreting cytokines,and promoting cytotoxic T lymphocyte(CTL)activation and display unique immunoregulatory capabilities through direct tumor cell killing or remodeling of the tumor microenvironment.The high heterogeneity and functional plasticity of CD4^(+)T cell subsets significantly influence clinical responses to immunotherapy with underlying mechanisms involving multi-level regulatory networks,including epigenetic modulation and metabolic reprogramming.Deciphering the functional heterogeneity of CD4^(+)T cells and the interactions with the tumor microenvironment will provide essential mechanistic insights for next-generation immunotherapies,such as immune checkpoint inhibitors and chimeric antigen receptor T(CAR-T)therapies,thereby advancing personalized treatment paradigms.
基金
supported by The National Key Research and Development Program of China(Grant No.2021YFA0910100)
Healthy Zhejiang One Million People Cohort(Grant No.K-20230085)
supported by National Natural Science Foundation of China(Grant Nos.82304946 and 82573745)
Post-doctoral Innovative Talent Support Program(Grant No.BX2023375)
567 Foundation of Zhejiang Province(Grant No.LMS25H160006)
supported by the National Natural Science Foundation of China(Grant No.82473489)
the Medical Science and Technology Project of Zhejiang Province(Grant No.WKJ-ZJ-2202)
the Natural Science Foundation of Zhejiang Province(Grant No.LBD24H290001)
supported by the National Natural Science Foundation of China(Grant No.82403546).
