摘要
评价高压氧治疗(Hyperbaric oxygen therapy,HBOT)在乳腺癌改良根治术后放疗中治疗放射性皮炎(Radiation dermatitis,RD)的效果,比较相关不良事件发生率,本研究为前瞻性研究。收集2023年12月至2024年12月唐山市人民医院放疗中心乳腺癌患者300例,将其随机均分为对照组和试验组。对照组接受一般急性RD干预,试验组在前者基础上增加HBOT。自放疗开始,对患者进行为期12周的随访,记为W_(1)~W_(12)。主要结局设置为急性RD等级,次要结局设置为数字分级评分法(Numerical rating scale,NRS)评分、皮肤病生活质量指数(Dermatology life quality index,DLQI)、Skindex-29、不良事件发生率。采用重复测量ANOVA和卡方检验比较上述结局。随访期间两组急性RD等级时间效应、组别效应、交互作用显著(均p<0.05),W_(8)~W_(12)期间试验组急性RD等级较低(均p<0.05)。随访期间两组NRS评分时间效应、组别效应、交互作用不显著(均p>0.05)。随访期间两组DLQI时间效应、组别效应、交互作用显著(均p<0.05),W_(8)~W_(12)期间试验组DLQI较低(均p<0.05)。随访期间两组Skindex-29时间效应、组别效应、交互作用显著(均p<0.05),W_(8)~W_(12)期间试验组Skindex-29较低(均p<0.05)。W_(12)时两组不良事件发生率差异不显著(χ^(2)=0.410,p=0.522)。HBOT针对乳腺癌患者急性RD的治疗效果较为理想,安全性可满足临床要求,具有一定的临床应用和推广价值。
This prospective study evaluated the effect of hyperbaric oxygen therapy(HBOT)on radiation dermatitis(RD)during postoperative radiotherapy after modified radical mastectomy for breast cancer,and compared the incidence of related adverse events.From December 2023 to December 2024,300 breast cancer patients treated at the Radiation Oncology Center of Tangshan People’s Hospital were enrolled and randomly assigned equally to a control group and an experimental group.The control group received standard interventions for acute RD,while the experimental group received HBOT in addition to the standard care.Starting from the beginning of radiotherapy,patients were followed for 12 weeks(recorded as W_(1)–W_(12)).The primary outcome was grade of acute RD;secondary outcomes included numerical rating scale(NRS)scores,dermatology life quality index(DLQI),Skindex-29,and incidence of adverse events.Repeated-measures ANOVA and chi-square tests were used to compare the outcomes above.During follow-up,time effects,group effects,and interactions for acute RD grade were all significant(all p<0.05),and the experimental group showed lower acute RD grades during W_(8)–W_(12)(all p<0.05).For NRS scores,time effects,group effects,and interactions were not significant(all p>0.05).For DLQI,time effects,group effects,and interactions were significant(all p<0.05),and the experimental group had lower DLQI scores during W_(8)–W_(12)(all p<0.05).For Skindex-29,time effects,group effects,and interactions were significant(all p<0.05),and the experimental group had lower Skindex-29 scores during W_(8)–W_(12)(all p<0.05).At W_(12),the difference in adverse event incidence between the two groups was not significant(χ^(2)=0.410,p=0.522).HBOT demonstrated a favorable therapeutic effect on acute RD in breast cancer patients and an acceptable safety profile for clinical use,indicating potential value for clinical application and wider adoption.
作者
时秀菊
黄昱霖
田龙
王蕊
SHI Xiuju;HUANG Yulin;TIAN Long;WANG Rui(Radiotherapy Center,Tangshan People's Hospital,Tangshan 063000,China;Department of Radiotherapy,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)
出处
《辐射研究与辐射工艺学报》
2026年第1期68-76,共9页
Journal of Radiation Research and Radiation Processing
基金
河北省医学科学研究课题计划(20242323)。
关键词
乳腺癌
改良根治术
急性
皮炎
治疗
不良事件
Breast cancer
Modified radical mastectomy
Acute
Dermatitis
Treatment
Adverse event
