摘要
肝癌是人类最常见的原发性癌症之一,是一种多因素诱导、多基因参与、机制复杂的恶性肿瘤。该病具有治疗难度大、预后差等特点,这些临床特征与其独特的肿瘤微环境构成密切相关。肝癌肿瘤微环境是一个由异质性细胞群体、可溶性细胞因子以及重塑的细胞外基质共同组成的动态生态系统。近年来,肝癌肿瘤微环境的研究取得了重要进展,揭示了其在肝癌发生、发展和治疗中的重要作用。本文综述了肝癌肿瘤微环境的关键调控要素,如肝星状细胞活化、免疫细胞功能失调、血小板异常、细胞外基质重塑等,以期为肝癌的防治策略提供理论依据。
Liver cancer,one of the most common primary malignancies in humans,is a malignant tumor characterized by multifactorial induction,polygenic involvement,and intricate molecular mechanisms.This disease is characterized by its treatment challenges and poor prognosis,which are closely related to its unique tumor microenvironment composition.The tumor microenvironment of liver cancer is a dynamic ecosystem composed of heterogeneous cellular populations,soluble cytokines,and remodeled extracellular matrix.In recent years,significant progress has been made in the study of the tumor microenvironment of liver cancer,revealed an important role in the occurrence,development,and treatment of liver cancer.The key regulatory elements of the tumor microenvironment in liver cancer were systematically summarized,such as activation of hepatic stellate cells,dysfunction of immune cells,abnormalities of platelet,and remodeling of the extracellular matrix,which provided theoretical foundations for prevention and treatment strategies against liver cancer.
作者
宋天豪
许维恒
王彦
陈莉
SONG Tianhao;XU Weiheng;WANG Yan;CHEN Li(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)
出处
《药学实践与服务》
2026年第2期65-70,共6页
Journal of Pharmaceutical Practice and Service
关键词
肝癌
微环境
肝星状细胞
免疫细胞
血小板
细胞外基质
liver cancer
microenvironment
hepatic stellate cells
immune cells
platelets
extracellular matrix
