摘要
目的调查分析妊娠期糖尿病(GDM)患者血清preptin、生长分化因子15(GDF-15)及肠道菌群变化特征与母婴结局的相关性。方法选取2021年1月至2022年12月在河南省人民医院产科进行产检的55例GDM孕妇作为GDM组,另外随机选取同一时间段在本院进行产检的55例非GDM孕妇作为非GDM组,比较两组孕妇的血清preptin水平、GDF-15、肠道菌群变化水平、妊娠结局。对比GDM组不同母婴结局孕妇血清preptin水平、GDF-15、肠道菌群变化水平。结果GDM组的空腹血糖(FBG)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平均高于非GDM组(P<0.05);GDM组的血清preptin、GDF-15水平较非GDM组升高(P<0.05);GDM组的肠杆菌、肠球菌菌落数较非GDM组升高,双歧杆菌、乳杆菌菌落数较非GDM组降低(P<0.05);两组共发生不良结局20例,其中GDM组15例,非GDM组5例。GDM组的早产和胎儿宫内窘迫发生率高于非GDM组(P<0.05)。GDM组中母婴结局良好患者血清preptin、GDF-15水平低于不良患者(P<0.05),肠杆菌、肠球菌菌落数低于不良患者,双歧杆菌、乳杆菌菌落数高于不良患者(P<0.05)。结论GDM孕妇的血清preptin、GDF-15水平异常升高,肠道菌群失调,且其水平变化与不良结局的发生有关。
Objective To explore the correlation between change characteristics of serum preptin,growth differentiation factor 15(GDF-15)and intestinal floras and maternal and neonatal outcomes in patients with gestational diabetes mellitus(GDM).Methods Fifty-five pregnant women with GDM who underwent antenatal examination at Henan Provincial People’s Hospital from January 2021 to December 2022 were enrolled as the GDM group.Another 55 pregnant women without GDM who had antenatal examination during the same period were randomly selected as the nonGDM group.The levels of serum preptin,GDF-15 and intestinal floras,and pregnancy outcomes were compared between the two groups.The levels of serum preptin,GDF-15 and intestinal floras were compared between GDM patients with favorable and adverse maternal-infant outcomes.Results The levels of FBG,TG,HbA1c,FINS and HOMA-IR in GDM group were higher than those in nonGDM group(P<0.05),and levels of serum preptin and GDF-15 were also higher than those in nonGDM group(P<0.05).The counts of Enterobacterium and Enterococcus in GDM group were higher than those in nonGDM group,while counts of Bifidobacteria and Lactobacillus were lower than those in nonGDM group(P<0.05).A total of 20 cases of adverse outcomes occurred in both groups,with 15 cases in GDM group and 5 cases in nonGDM group.The incidence of adverse maternal and neonatal outcomes in GDM group was higher than that in nonGDM group(P<0.05).Within the GDM group,the levels of serum preptin and GDF-15 in patients with good maternal and infant outcomes were lower than those in patients with poor outcomes(P<0.05),the counts of Enterobacterium and Enterococcus were lower than those in adverse pregnancy group,while counts of Bifidobacteria and Lactobacillus were higher than those in adverse pregnancy group(P<0.05).Conclusion There levels of serum preptin and GDF-15 are abnormally increased,and intestinal floras are disordered in pregnant women with GDM,and the above changes are related to the occurrence of adverse pregnancy.
作者
赵琳
王焕萍
张敬丽
武海英
ZHAO Lin;WANG Huanping;ZHANG Jingli;WU Haiying(Department of Obstetrics and Gynecology,Henan Provincial People’s Hospital,Zhengzhou 450000,China)
出处
《河南医学研究》
2026年第3期438-442,共5页
Henan Medical Research
关键词
妊娠期糖尿病
血清preptin
生长分化因子15
肠道菌群变化特征
母婴结局
gestational diabetes mellitus
serum preptin
growth differentiation factor 15
change characteristic of intestinal flora
maternal and neonatal outcome
