摘要
目的探讨中国18个长寿地区≥65岁老年人甲状腺激素水平与体质指数(BMI)、腰围和体成分的关联。方法基于中国老年健康生物标志物队列研究2021年横断面研究数据,共纳入4566名研究对象。采用多重线性回归模型和限制性立方样条模型分析各种甲状腺激素水平与BMI、腰围、肌肉量和脂肪量的关联,并根据性别、年龄和水产品摄入进行分层分析。结果研究对象年龄为(82.6±10.5)岁,男性占47.5%,游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平分别为(4.2±0.6)pmol/L和(15.4±2.2)pmol/L。多重线性回归模型分析结果显示,调整混杂因素后,FT3每增加1个单位,BMI、腰围、肌肉量和脂肪量的平均变化水平β值(95%CI)分别为0.64(0.44~0.83)、1.21(0.66~1.76)、0.22(0.03~0.41)和1.44(1.05~1.84);FT4每增加1个单位,肌肉量的平均变化水平β值(95%CI)为-0.15(-0.19~-0.10)。限制性立方样条分析结果显示,FT3与BMI、腰围、肌肉量和脂肪量均呈正向非线性关联(非线性均P<0.05);FT4仅与肌肉量呈负向线性关联(线性P<0.001)。结论中国18个长寿地区≥65岁老年人FT3与BMI、腰围和体成分呈正向关联,FT4与肌肉量呈负向关联。
Objective To understand the association of thyroid hormone level with body mass index(BMI),waist circumference and body composition in older adults aged≥65 years in 18 longevity areas in China.Methods Based on cross-sectional data from the 2021 China Healthy Ageing and Biomarkers Cohort Study,4566 older adults aged≥65 years were included in this study.Multiple linear regression and restricted cubic spline models was used to analyze the associations of thyroid hormone level with BMI,waist circumference,muscle mass,and fat mass.Stratified analyses were performed according to gender,age,and fish intake of the older adults.Results The mean age of the older adults was(82.6±10.5)years,47.5%of them were men,the free triiodothyronine(FT3)and free thyroxine(FT4)levels were(4.2±0.6)pmol/L and(15.4±2.2)pmol/L respectively.After controlling confounding factors,the results of the multiple linear regression model showed that for each increment of 1 pmol/L in FT3 level,the mean levelsβ(95%CI)of change in BMI,waist circumference,muscle mass,and fat mass was 0.64(0.44-0.83),1.21(0.66-1.76),0.22(0.03-0.41),and 1.44(1.05-1.84)respectively.The mean change in muscle mass for each increment of 1 pmol/L in FT4 level was-0.15(-0.19--0.10).The restricted cubic spline analysis showed that positive nonlinear associations of FT3 with BMI,waist circumference,muscle mass,and fat mass(all P for nonlinear<0.05)and negative linear association between FT4 and muscle mass(P for linear<0.001).Conclusions In the older adults aged≥65 years in 18 longevity areas in China,FT3 level was positively associated with the changes of BMI,waist circumference and body composition.FT4 level was negatively correlated with muscle mass.
作者
杨静静
陈家豪
陈晨
马晓燕
吴昌恣
孟熙
赵玉明
许航
符小霜
陈永强
陈思睿
朱子月
李志培
吕跃斌
施小明
Yang Jingjing;Chen Jiahao;Chen Chen;Ma Xiaoyan;Wu Changzi;Meng Xi;Zhao Yuming;Xu Hang;Fu Xiaoshuang;Chen Yongqiang;Chen Sirui;Zhu Ziyue;Li Zhipei;Lyu Yuebin;Shi Xiaoming(Department of Epidemiology,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China;China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou 510515,China;Department of Occupational and Environmental Health,School of Public Health,Jilin University,Changchun 130021,China)
出处
《中华流行病学杂志》
北大核心
2026年第1期37-45,共9页
Chinese Journal of Epidemiology
基金
国家重点研发计划(2023YFC3603400)
国家自然科学基金(82025030,82222063,82230111)
四大慢病重大专项(2023ZD0519200)。
关键词
甲状腺激素
老年人
横断面研究
体质指数
体成分
Thyroid hormones
Older adults
Cross-sectional study
Body mass index
Body composition
