摘要
目的比较分析纤维支气管镜刷片、肺泡灌洗液离心涂片(BALF)及纤维支气管镜刷液基薄层细胞学制片(TCT)中单种及联合检测方法。方法回顾性分析广东省人民医院赣州医院(赣州市立医院)2020年1月至2023年5月116例病理确诊肺癌患者的细胞学检查结果,比较刷片(n=109)、液基薄层制片(n=108)、灌洗液涂片(n=31)制片中单种及联合检测的阳性率,采用卡方检验进行统计学分析。结果116例肺癌确诊病例检测结果中,分析刷片、液基薄层制片(TCT)、灌洗液涂片(BALF)、刷片+液基薄层制片(TCT)、刷片+灌洗液涂片(BALF)、液基薄层制片(TCT)+灌洗液涂片(BALF)诊断阳性率分别为70.6%、69.4%、29.0%、78.8%、66.7%、66.7%。发现在单种检测方法中,刷片与液基薄层制片(TCT)阳性率无显著差异(70.6%vs 69.4%,P>0.05),均显著高于灌洗液涂片BALF(29.0%,P<0.001);联合检测中,刷片+TCT阳性率最高(78.8%),优于刷片+BALF(66.7%)或TCT+BALF(66.7%)(χ^(2)=27.996,P<0.001)。结论在肺癌细胞学筛查方式中,刷片与TCT单独检测效能相当,而二者联合可显著提高肺癌细胞学诊断阳性率,推荐作为临床优先选择的检测策略。
Objective To compare and analyze the positive rates of single and combined detection methods in bronchofibroscopic brush smear,centrifugal smear of alveolar lavage fluid and liquid-based thin-layer cytology of bronchofibroscopic brush,and to explore the most effective cytological detection method for lung cancer screening.Methods The cytological examination results of 116 patients with lung cancer diagnosed by pathology were analyzed retrospectively,and the brush smears compared(n=109),the positive rates of single and combined detection in liquid-based thin-layer cytology(n=108)and lavage fluid smear(n=31)were statistically analyzed by chi-square test.Results Among 116 confirmed cases of lung cancer,brush,liquid-based thin-layer cytology(TCT),lavage fluid smear(BALF),brush+liquid-based thin-layer cytology,brush+lavage fluid smear(BALF)and liquid-based thin-layer cytology+lavage fluid smear(BALF)were analyzed;the positive rates of diagnosis were 70.6%,69.4%,29.0%,78.8%,66.7%and 66.7%,respectively.It was found that there was no significant difference in the positive rate between brush smear and liquid-based thin-layer chromatography(TCT)(70.6%vs.69.4%,P>0.05),but they were significantly higher than BALF of lavage fluid smear(29.0%,P<0.001).The positive rate of brush+TCT was the highest(78.8%),which was better than brush+BALF(66.7%)or TCT+BALF(66.7%)(χ^(2)=27.996,P<0.001).Conclusion In the cytological screening of lung cancer,brushing and TCT alone have the same detection efficiency,and the combination of them can significantly improve the positive rate of cytological diagnosis of lung cancer,which is recommended as the preferred detection strategy in clinic.
作者
邓储婷
黎兵兵
郑益红
黄慧春
林敏
黄加宾
DENG Chuting;LI Bingbing;ZHENG Yihong;HUANG Huichun;LIN Min;HUANG Jiabin(Department of Pathology,Guangdong Provincial People's Hospital Ganzhou Hospital/Ganzhou Municipal Hospital,Ganzhou 341000,China;Department of General Practice,Ganjiang Community Health Service Center,Ganzhou 341000,China;Changsha Medical College,Changsha 410000,China)
出处
《诊断病理学杂志》
2026年第1期100-104,共5页
Chinese Journal of Diagnostic Pathology
基金
赣州市指导性科技计划项目(GZ2024ZSF086)。
关键词
肺癌
取样方法
细胞学
诊断效率
联合检测
lung cancer
sampling method
cytology
diagnositic efficiency
combined testing
