摘要
b型流感嗜血杆菌(Haemophilus influenzae type b,Hib)可引起儿童侵袭性感染,造成多种疾病。许多国家已将含Hib成分疫苗纳入免疫规划,但在含Hib成分疫苗接种率较低的国家Hib疾病负担仍然较重。含Hib成分疫苗与多种儿童常规接种疫苗的免疫程序高度重合,同时接种可提高疫苗接种率。本文对含Hib成分疫苗与其他疫苗同时接种的安全性和免疫原性进行文献综述,并依据各国指导文件和疫苗说明书归纳了同时接种的相关建议,为完善中国含Hib成分疫苗接种策略提供参考。
Haemophilus influenzae type b(Hib)causes invasive infections in children and leads to a variety of severe diseases.Hib-containing vaccines have been introduced into national immunization programs of many countries,however,Hib-related disease burden is substantial in nations with low coverage of Hib-containing vaccine.Immunization schedules of Hib-containing vaccines largely overlap with routine immunization schedules of many childhood vaccines.Therefore,simultaneous vaccination has potential to effectively improve vaccine coverage.In this article,we review the safety and immunogenicity of Hib-containing vaccines co-administered with other vaccines and summarize recommendations for simultaneous vaccination based on guidance documents of various countries and vaccine package inserts,aiming to provide reference for optimizing vaccination strategies for Hib-containing vaccines in China.
作者
刘萌
李军宏
刘晓雪
吴雨晓
王亚敏
宋渝丹
安志杰
尹遵栋
马超
Liu Meng;Li Junhong;Liu Xiaoxue;Wu Yuxiao;Wang Yamin;Song Yudan;An Zhijie;Yin Zundong;Ma Chao(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention(Chinese Academy of Preventive Medicine),Beijing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention(Chinese Academy of Preventive Medicine),Beijing 100050,China)
出处
《中国疫苗和免疫》
北大核心
2025年第6期751-758,共8页
Chinese Journal of Vaccines and Immunization
基金
中国疾病预防控制中心公共卫生应急反应机制的运行(102393220020010000017)。
关键词
b型流感嗜血杆菌疫苗
同时接种
安全性
免疫原性
Haemophilus influenzae type b vaccine
Simultaneous vaccination
Safety
Immunogenicity
