摘要
肠道微生态是人体第二大虚拟器官,其平衡与紊乱影响多种消化道疾病的发生与发展。在肠道菌群中嗜黏蛋白阿克曼菌(Akkermansia muciniphila,Akk)是治疗消化道疾病最具有潜力的益生菌之一,其外膜蛋白Amuc_1100更是起到了改善肠道屏障功能及调节免疫稳态的关键作用,但其具体机制异常复杂,是当前医学研究的热点。本文综述了Amuc_1100在消化道疾病中的作用及调节机制,并探讨了其在药物开发和治疗中的应用前景,以期加强对以Akk为代表的肠道微生物群与宿主相互作用机制的理解,为相关消化道疾病的新干预策略奠定基础。
Intestinal microecology is the second largest virtual organ of the human body,and its balance and disorder affect the occurrence and development of a variety of digestive tract diseases.Among the intestinal flora,Akkermansia muciniphila(Akk)is one of the most promising probiotics for the treatment of digestive tract diseases,and its outer membrane protein Amuc_1100 plays a key role in improving intestinal barrier function and regulating immune homeostasis.However,its specific mechanism is extremely complex,which is the focus of current medical research.This article reviewed the role and regulatory mechanism of Amuc_1100 in digestive tract diseases,and discussed its application prospects in drug development and treatment,in order to strengthen the understanding of the interaction mechanism between intestinal microflora represented by Akk bacteria and the host,and lay the foundation for new intervention strategies for related digestive tract diseases.
作者
李向向
高浏璐
邓渊
朱惠娟
张照杰
於兵霞
于晓辉
LI Xiangxiang;GAO Liulu;DENG Yuan;ZHU Huijuan;ZHANG Zhaojie;YU Bingxia;YU Xiaohui(College of Integrative Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000;Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of Chinese PLA;Laboratory of Basic Medicine,the 940th Hospital of Joint Logistics Support Force of Chinese PLA,Gansu Province Stem Cell and Gene Medicine Laboratory,China)
出处
《胃肠病学和肝病学杂志》
2026年第2期304-307,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
国家重大战略需求和地方经济社会发展专项(31920250079)
兰州市科技计划项目(2023-ZD-181)
甘肃省青年科技基金(23JRRA1675)
九四〇医院基金临床医学肝病诊治中心(2021yxky079)。
