摘要
流行性乙型脑炎(Japanese encephalitis,JE;简称乙脑)是由流行性乙型脑炎病毒(Japanese encephalitis virus,JEV)引起、经媒介蚊虫叮咬而传播的一种中枢神经系统感染的急性传染病,JEV仅有1种血清型,但可分为5种基因型(G-Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ)。本病广泛流行于亚洲地区,东南亚地区是JEV起源及主要流行地区。云南省与东南亚诸国相邻,属于我国JE主要流行区之一。云南省存在G-Ⅲ和G-ⅠJEV流行,为亚洲最早分离到G-Ⅰ的地区,在我国JEV传播扩散中具有重要作用。本文对历年来云南省JEV分离株的基因分型及其JEV起源、遗传进化研究和流行病学特征进行综述,为深入开展相关研究和防控工作提供参考资料。
Japanese encephalitis(JE)is an acute infectious disease of the central nervous system caused by Japanese encephalitis virus(JEV),which is mainly transmitted by bites of Culex tritaeniorhynchus mosquitoes.The JEV has only one serotype but can be divided into five genotypes(G-Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ).The JE is widely prevalent in Asia,with Southeast Asia being the origin and main epidemic area of JEV.Yunnan province is adjacent to Southeast Asian countries and belongs to one of the main epidemic areas of JE in China.Yunnan province is home to the prevalence of G-Ⅲ and G-Ⅰ of JEV.It is also the first place in Asia where the G-Ⅰ of JEV was isolated.It plays an important role in the transmission and spread of JEV in China.This paper reviews the genotyping of JEV isolates from Yunnan province over the years,as well as research on the origin,genetic evolution of JEV and its epidemiological characteristics,so to provide reference data for further in-depth research and prevention and control of JE.
作者
张海林
Zhang Hailin(Yunnan Institute of Endemic Diseases Control and Prevention,Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention,Kunming 650500,China)
出处
《中华实验和临床病毒学杂志》
2025年第6期808-815,共8页
Chinese Journal of Experimental and Clinical Virology
关键词
流行性乙型脑炎
流行性乙型脑炎病毒
基因型
遗传进化
流行病学特征
Japanese encephalitis
Japanese encephalitis virus
Genotype
Genetic evolution
Epidemiological characteristics
