摘要
随着分子生物学技术的进步和中药药理学研究的深入,越来越多中药及复方的药理机制被逐步阐明。在此基础上,提出基于中医基本病机与现代医学的病理生理机制,结合中医药传统方药功效与现代药理学研究成果,构建“中医基本病机-病理生理机制”联合的中西医结合病机辨治方法。在诊断层面,“中医基本病机-病理生理机制”联合的辨治模式既能反映疾病的中医病机本质,又能全面反映疾病的各层面病理变化;在治疗层面,该模式可辅助医生为患者选择既能针对中医病机发挥治疗作用,又能对疾病病理生理机制及相关临床指标产生明确药理作用的方药。今后,“中医基本病机-病理生理机制”联合的中西医结合病机辨治方法还可借助表型组学技术实现中医病机判定的客观化,并在立足方药功效的基础上,结合中药药理学研究成果提升遣方用药的精准性,既有助于提高中医临床疗效,又能推动现代疾病中医病机体系与诊疗体系的完善,促进当代中医诊疗模式的革新。
With the advancement of molecular biology technology and the in-depth research of the pharmacology of traditional Chinese medicine(TCM),the pharmacological mechanisms of more and more Chinese materia medica and their formulas have been gradually clarified.By coordinating the basic pathogenesis of TCM with the pathological and physiological mechanisms of modern medicine,and combining the efficacy of TCM formulas with the results of modern pharmacological research,a method for pathogenesis differentiation and treatment based on"TCM basic pathogenesis/pathophysiological mechanisms"through integrated Chinese and western medicine was constructed.This method selects prescriptions that can not only exert therapeutic effects targeting TCM pathogenesis but also produce definite pharmacological effects on modern pathophysiological mechanisms and related clinical indicators for treatment.Phenomics technology was used to realize objective judgment of TCM pathogenesis,and based on the efficacy of formulas,the precision of prescription could improve based on the results of TCM pharmacological research.This not only helps improve the clinical efficacy of TCM but also promote the improvement of the TCM pathogenesis system and diagnosis-treatment system for modern diseases,thereby facilitating the innovation of contemporary TCM diagnosis and treatment models.
作者
胡锦浩
杨金生
石岩
李宁
陈曦
荆业腾
HU Jinhao;YANG Jinsheng;SHI Yan;LI Ning;CHEN Xi;JING Yeteng(Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing,100700;Liaoning University of Traditional Chinese Medicine)
出处
《中医杂志》
北大核心
2026年第2期121-125,共5页
Journal of Traditional Chinese Medicine
基金
国家中医药管理局高水平中医药重点学科建设项目(KYG202407)。
关键词
中医基本病机
病理生理机制
中西医结合
病机辨治
basic pathogenesis of traditional Chinese medicine
pathophysiological mechanism
integration of Chinese and western medicine
pathogenesis differentiation and treatment
