摘要
目的通过无创肝纤维化指标和脂肪衰减参数观察芪茵颗粒治疗代谢相关脂肪性肝病(MAFLD)的临床疗效。方法选取2023年1月~2024年1月入院,符合纳排标准的MAFLD患者70例,随机分为:对照组、芪茵组。两组患者于受试期间进行健康宣教,坚持健康生活方式等基础治疗,对照组患者予基础治疗,芪茵组患者在基础治疗上予芪茵颗粒,两组疗程均为12周。两组患者予治疗后分别观察:肝功能(ALT、AST、GGT、TBIL、DBIL、IBIL)、血脂(TG、TC、HDL-C、LDL-C、VLDL-C)、血糖(FPG)、肝纤维化评分(NFS、APRI、FIB-4、BARD、LSM)、脂肪变性程度(CAP)、安全性评价。结果治疗后,与对照组相比,芪茵组患者的ALT、AST、TG、VLDL-C、CAP明显下降,HDL-C显著升高,中重度脂肪变性占比显著降低,脂肪变性疗效的有效率较高(P<0.05),而肝纤维化程度和分期差异无统计学意义(P>0.05)。结论在健康生活方式指导下,芪茵颗粒可以改善MAFLD患者肝功能、血脂、脂肪变性程度,疗效显著。
Objective To observe the clinical efficacy of Qiyin granules in the treatment of metabolic associated fatty liver disease(MAFLD)by noninvasive liver fibrosis indices and fat attenuation parameters.Methods From January 2023 to January 2024,a total of 70 patients diagnosed with MAFLD were enrolled and randomly divided into the control group and Qiyin group.During this period,both groups of patients received health education and basic treatments such as maintaining a healthy lifestyle.The control group received only basic treatment,while Qiyin group received Qiyin granules in addition to the basic treatment.The treatment course for both groups was 12 weeks.After the treatment,the following aspects of the two groups of patients were observed:Liver function(ALT,AST,GGT,TBIL,DBIL,IBIL),blood lipids(TG,TC,HDL-C,LDL-C,VLDL-C),blood glucose(FPG),liver fibrosis score(NFS,APRI,FIB-4,BARD,LSM),degree of steatosis(CAP),and safety evaluation.Results After treatment,compared with the control group,ALT,AST,TG,VLDL-C and CAP in Qiyin group were significantly decreased,HDL-C was significantly increased,the proportion of moderate and severe steatosis was significantly decreased,and higher efficacy rates of steatosis efficacy(P<0.05).There was no statistically significant difference in the degree and staging of liver fibrosis(P>0.05).Conclusion With the guidance of healthy lifestyle,Qiyin granules can reverse the liver function,blood lipid and steatosis degree of MAFLD patients.
作者
刘云霄
王晓忠
LIU Yunxiao;WANG Xiaozhong(Key Laboratory,Lishui People's Hospital,Lishui 323000,China;Department of Hepatology,Traditional Chinese Medicine Hospital Affiliated of Xinjiang Medical University,Urumqi 830000,China)
出处
《四川中医》
2026年第1期91-97,共7页
Journal of Sichuan of Traditional Chinese Medicine
基金
新疆医科大学2023年自治区研究生创新项目(XJ2023G183)
丽水市人民医院博士后科研基金(2024bsh005)
2026年度国家中医药综合改革示范区科技共建项目(GZY-KJS-ZJ2026-152)。
关键词
芪茵颗粒
代谢相关脂肪性肝病
瞬时弹性成像
临床疗效
Qiyin granules
Metabolic associated fatty liver disease
Transient elastography
Clinical efficacy
