摘要
网膜转移被认为是进展期胃癌中最常见的转移途径之一,同时也是导致晚期胃癌患者预后不良的关键因素,关于胃癌网膜转移的机制,国内外研究已广泛聚焦于多个层面,主要包括肿瘤微环境、基因、黏附分子、外泌体、钙网蛋白、补体等。而这些因素都是在游离的癌细胞在腹腔内定植基础上产生作用的,本文回顾了近年来关于胃癌网膜转移相关机制的国内外研究进展,并分析了其潜在的研究价值与应用前景。
Omental metastasis is recognized as one of the most common pathways of metastasis in advanced gastric cancer and is also a key factor contributing to poor prognosis in patients with advanced gastric cancer.Research has extensively focused on various aspects concerning the mechanisms of gastric cancer omental metastasis,including the tumor microenvironment,genes,adhesion molecules,exosomes,calreticulin,and complement.These factors act on the basis of the implantation of free cancer cells in the abdominal cavity.This article reviews recent advances in understanding the mechanisms of gastric cancer omental metastasis and discusses their potential research and clinical implications.
作者
隆方文
郑侠
钱军
章宜芬
LONG Fangwen;ZHENG Xia;QIAN Jun;ZHANG Yifen(Department of Oncology,the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210004;Jiangsu Collaborative lnnovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor,Nanjing University of Chinese Medicine,Nanjing 210004;Department of Pathology,the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210004,China)
出处
《基础医学与临床》
2026年第2期282-287,共6页
Basic and Clinical Medicine
基金
江苏省中医药管理局(MS2023014)。
关键词
胃癌
网膜转移
机制研究
gastric cancer
omental metastasis
mechanism research
