摘要
目的观察腹膜透析联合血液透析对尿毒症患者心功能和营养指标的影响。方法将南阳市中心医院2021年1月至2025年3月期间收治的70例尿毒症患者采用随机数字表法分为两组,每组35例。对照组采用单纯腹膜透析治疗,研究组在对照组治疗基础上加用血液透析治疗。两组均连续治疗6个月后判定疗效。对比两组心脏超声参数(包括左心室射血分数、左心室舒张末期容积、左心室后壁厚度)、营养状况指标(包括白蛋白、前白蛋白和血红蛋白)、肾功能指标(包括血尿素氮、血肌酐)、透析充分性[采用总每周尿素清除指数(Kt/V)评估]及并发症发生率。结果治疗后,研究组左心室射血分数高于对照组,左心室后壁厚度低于对照组,差异有统计学意义(P<0.05)。两组治疗后左心室舒张末期容积比较,差异无统计学意义(P>0.05)。治疗后,研究组血清前白蛋白、白蛋白、血红蛋白水平高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组血尿素氮、血肌酐水平低于对照组,差异有统计学意义(P<0.05)。研究组总每周Kt/V大于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论腹膜透析联合血液透析可改善尿毒症患者的心功能、营养状况、肾功能及透析充分性,可能有助于改善与预后相关的指标。
Objective To observe the effects of peritoneal dialysis combined with hemodialysis on cardiac function and nutritional indices in uremic patients.Methods A total of 70 uremic patients admitted to Nanyang Central Hospital between January 2021 and March 2025 were assigned.using a random number table method.to two groups(35 cases in each group).The control group received peritoneal dialysis alone.and the study group received additional hemodialysis on the basis of peritoneal dialysis.After 6 consecutive months of treatment.efficacy was evaluated.Cardiac ultrasound parameters(including left ventricular ejection fraction.left ventricular end-diastolic volume.and left ventricular posterior wall thickness).nutritional status indices(including albumin.prealbumin.and hemoglobin).renal function indices(including blood urea nitrogen and serum creatinine).dialysis adequacy[assessed by total weekly urea clearance index(Kt/V)].and complication rates were compared between the two groups.Results After treatment.the study group had a higher left ventricular ejection fraction and a lower left ventricular posterior wall thickness than the control group.with statistically significant differences(P<0.05).There was no statistically significant difference in left ventricular end-diastolic volume between the two groups after treatment(P>0.05).After treatment.serum prealbumin.albumin.and hemoglobin levels were higher in the study group than in the control group.with statistically significant differences(P<0.05).After treatment.blood urea nitrogen and serum creatinine levels were lower in the study group than in the control group.with statistically significant differences(P<0.05).Total weekly Kt/V was greater in the study group than in the control group.with a statistically significant difference(P<0.05).The complication rate did not differ significantly between the two groups(P>0.05).Conclusion Peritoneal dialysis combined with hemodialysis can improve cardiac function.nutritional status.renal function.and dialysis adequacy in uremic patients.and may help improve indicators associated with prognosis.
作者
谷裕
石新慧
鲁冰
任东升
GU Yu;SHI Xinhui;LU Bing;REN Dongsheng(Department of Nephrology,Nanyang Central Hospital,Nanyang Henan 473000,China)
出处
《临床研究》
2026年第2期93-96,共4页
Clinical Research
关键词
尿毒症
腹膜透析
血液透析
心功能
营养指标
肾功能
uremia
peritoneal dialysis
hemodialysis
cardiac function
nutritional indices
renal function
