摘要
目的探讨支气管肺泡灌洗联合多西环素治疗肺炎支原体肺炎(MPP)患儿的临床疗效。方法采用回顾性研究方法,选择濮阳市人民医院2023年6月至2024年6月接受支气管肺泡灌洗联合多西环素治疗的MPP患儿37例作为观察组,同期接受多西环素治疗的MPP患儿36例作为对照组。两组均给予常规对症治疗。对照组给予注射用盐酸多西环素静脉滴注,观察组在对照组治疗基础上加用支气管肺泡灌洗治疗。两组均治疗10 d后判定疗效。比较两组肺功能指标[包括用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))和呼气流量峰值(PEF)]、炎症因子[包括白细胞介素-6(IL-6)和肿瘤坏死因子α(TNF-α)]、实验室指标[包括C反应蛋白(CRP)、白细胞计数(WBC)和红细胞沉降率(ESR)]及不良反应。结果两组治疗有效率比较,差异无统计学意义(P>0.05);两组疗效分布情况比较,差异有统计学意义(P<0.05)。治疗后,两组FVC、FEV_(1)及PEF均升高,且观察组高于对照组,差异有统计学意义(P<0.05);两组IL-6、TNF-α、WBC、CRP、ESR水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应比较无统计学差异(P>0.05)。结论支气管肺泡灌洗联合多西环素治疗在本回顾性研究中显示出更优的疗效分布,且肺功能指标改善、炎症指标下降更明显,安全性良好。
Objective To investigate the clinical efficacy of bronchoalveolar lavage combined with doxycycline in children with Mycoplasma pneumoniae pneumonia(MPP).Methods This retrospective study enrolled 37 children with MPP who received bronchoalveolar lavage combined with doxycycline at Puyang People’s Hospital from June 2023 to June 2024 as the observation group.and 36 children with MPP who received doxycycline alone during the same period as the control group.Both groups received routine symptomatic and supportive treatment.The control group was given intravenous infusion of doxycycline hydrochloride for injection.and the observation group additionally underwent bronchoalveolar lavage on the basis of the treatment administered to the control group.Treatment efficacy was evaluated after 10 days of therapy in both groups.Pulmonary function parameters.including forced vital capacity(FVC).forced expiratory volume in 1 second(FEV_(1)).and peak expiratory flow(PEF);inflammatory cytokines.including interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α);laboratory indicators.including C-reactive protein(CRP).white blood cell count(WBC).and erythrocyte sedimentation rate(ESR);and adverse reactions were compared between the two groups.Results There was no statistically significant difference in the overall response rate between the two groups(P>0.05).However.the distribution of therapeutic efficacy differed significantly between the two groups(P<0.05).After treatment.FVC.FEV_(1).and PEF increased in both groups.and these values were higher in the observation group than in the control group;the differences were statistically significant(P<0.05).Levels of IL-6.TNF-α.WBC.CRP.and ESR decreased in both groups after treatment.and these levels were lower in the observation group than in the control group;the differences were statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion In this retrospective study.bronchoalveolar lavage combined with doxycycline treatment demonstrated superior efficacy distribution.with more pronounced improvements in lung function indicators and reductions in inflammatory markers.while maintaining good safety..
作者
郭晓冉
时利玲
王玮
张俊霞
张敬芳
聂钊
GUO Xiaoran;SHI Liling;WANG Wei;ZHANG Junxia;ZHANG Jingfang;NIE Zhao(Second Pediatric Ward,Puyang People’s Hospital,Puyang Henan 457000,China;Department of Pediatrics,The Third People’s Hospital of Henan Provincial,Zhengzhou Henan 450000,China)
出处
《临床研究》
2026年第2期57-60,共4页
Clinical Research
关键词
多西环素
支气管肺泡灌洗
肺炎支原体肺炎
临床疗效
doxycycline
bronchoalveolar lavage
Mycoplasma pneumoniae pneumonia
clinical efficacy
