摘要
目的基于二元Logistic回归分析二尖瓣关闭不全(MR)患者冠脉搭桥术(CABG)术后发生低氧血症的相关因素,以期为临床早期制定相应干预方案、降低患者低氧血症发生风险提供参考。方法回顾性选取2021年5月至2025年5月郑州市第七人民医院收治的MR行CABG术患者200例,根据术后是否发生低氧血症分为发生组(n=56)和未发生组(n=144),比较两组临床资料,采用二元Logistic回归分析MR患者CABG术后发生低氧血症的相关因素。结果发生组术前LVEF显著低于未发生组,差异有统计学意义(P<0.05),且发生组中体外循环时间>120 min、术中液体超负荷、未采用肺保护性通气、有吸烟史、术后镇痛不充分的比例均显著高于未发生组,差异均有统计学意义(P<0.05);经二元Logistic回归分析结果显示,体外循环时间>120 min、术中液体超负荷、未采用肺保护性通气、吸烟史、术后镇痛不充分均为MR患者CABG术后发生低氧血症的相关因素(P<0.05)。结论体外循环时间>120 min、术中液体超负荷、未采用肺保护性通气、吸烟史、术后镇痛不充分均为MR患者CABG术后低氧血症的相关因素,可为临床评估术后低氧血症发生风险、制定相应干预方案提供参考。
Objective To identify factors associated with postoperative hypoxemia after coronary artery bypass grafting(CABG)in patients with mitral regurgitation(MR)using binary logistic regression analysis.thereby providing evidence for early development of targeted interventions and reduction of hypoxemia risk.Methods This retrospective study included 200 patients with MR who underwent CABG in our hospital from May 2021 to May 2025.According to whether postoperative hypoxemia occurred.patients were assigned to the hypoxemia group(n=56)or the non-hypoxemia group(n=144).Clinical characteristics were compared between the two groups.Binary logistic regression analysis was performed to determine factors associated with postoperative hypoxemia in MR patients after CABG.Results Preoperative left ventricular ejection fraction(LVEF)in the hypoxemia group was significantly lower than that in the non-hypoxemia group(P<0.05).Moreover.the proportions of cardiopulmonary bypass(CPB)time>120 min.intraoperative fluid overload.absence of lung-protective ventilation.a history of smoking.and inadequate postoperative analgesia were significantly higher in the hypoxemia group than in the non-hypoxemia group(P<0.05).Binary logistic regression analysis showed that CPB time>120 min.intraoperative fluid overload.absence of lung-protective ventilation.a history of smoking.and inadequate postoperative analgesia were factors associated with postoperative hypoxemia in MR patients after CABG(P<0.05).Conclusion CPB time>120 min.intraoperative fluid overload.absence of lung-protective ventilation.a history of smoking.and inadequate postoperative analgesia are associated factors for postoperative hypoxemia after CABG in patients with MR.These findings provide a reference for clinical risk assessment of postoperative hypoxemia and for developing corresponding intervention strategies.
作者
陈英
袁超
段正伟
常峰荣
赵俊涛
CHEN Ying;YUAN Chao;DUAN Zhengwei;CHANG Fengrong;ZHAO Juntao(CSICU,Zhengzhou Seventh People’s Hospital,Zhengzhou Henan 450000,China;Department of Cardiothoracic Surgery,Zhengzhou Seventh People’s Hospital,Zhengzhou Henan 450000,China)
出处
《临床研究》
2026年第2期6-9,共4页
Clinical Research
基金
2024年度郑州市医疗卫生领域科技创新指导计划(2024YLZDJH229)。
关键词
二尖瓣关闭不全
冠脉搭桥术
低氧血症
相关因素
mitral regurgitation
coronary artery bypass grafting
hypoxemia
associated factors
