摘要
目的:评价胃复春逆转胃低级别上皮内瘤变(LGIN)的疗效。方法:选择2022年1月至2025年7月深圳市龙岗中心医院收治的103例胃镜病理活组织检查(以下简称活检)诊断为慢性胃炎伴LGIN的患者,随机分为观察组(n=49)和对照组(n=54)。观察组采用胃复春治疗,对照组采用替普瑞酮治疗,疗程均为12周,之后复查胃镜并进行病理活检。比较两组治疗后的临床疗效和组织病理学疗效。结果:观察组的症状改善率为73.47%,对照组的症状改善率为68.52%,差异无统计学意义(P>0.05)。观察组胃黏膜LGIN消退率为75.51%,对照组胃黏膜LGIN消退率为55.56%,差异有统计学意义(P<0.05)。结论:胃复春可有效缓解胃黏膜LGIN患者临床症状,消退部分低级别瘤变病灶。
Objective:To evaluate the treatment efficacy of weifuchun in reversing low-grade gastric intraepithelial neoplasia(LGIN).Methods:From January 2022 to July 2025,103 patients diagnosed as chronic gastritis with LGIN by gastroscopy pathological biopsy in shenzhen longgang central hospital were randomly divided into observation group(n=49)and control group(n=54).The observation group was treated with metoclopramide,while the control group was treated with teprenone orally for 12 weeks.After that,gastroscopy and pathological biopsy were performed.The clinical and histopathological effects were compared between the two groups after treatment.Results:The improvement rate of symptoms in the observation group was 73.46%,while that in the control group was 68.52%,with no statistical significance(P>0.05).The regression rate of gastric LGIN in the observation group was 75.51%,while that in the control group was 55.56%,the difference was statistically significant(P<0.05).Conclusion:Weifuchun can effectively relieve the clinical symptoms of patients with gastric LGIN and eliminate some low-grade tumor lesions.
作者
李世通
张宏聪
刘芸
杨兵
LI Shitong;ZHAGN Hongcong;LIU Yun;YANG Bing(Longgang District Central Hospital of Shenzhen,Shenzhen 518116,China)
出处
《临床医药实践》
2026年第2期115-117,147,共4页
Proceeding of Clinical Medicine
关键词
低级别上皮内瘤变
慢性胃炎
肠上皮化生
胃复春
替普瑞酮
low-grade gastric intraepithelial neoplasia
chronic gastritis
intestinal metaplasia
weifuchun
teprenone
