摘要
Michael加成和aldol反应是有机合成中最为经典的两类反应.通过底物设计以及对反应条件的调控,可使二者在同一体系中先后发生以生成环状分子骨架,这一连续反应被称为Michael/aldol串联环化反应.该反应有效提高了合成复杂环系化合物的原子经济性和步骤经济性.以四十余篇已报道的天然产物合成研究为例,根据Michael/aldol反应的先后顺序及亲核原子的类型,归纳了九类常见的Michael/aldol串联环化反应,展示了它们作为关键步骤在天然产物合成中的应用,并展望了该方法的进一步发展潜力.
In modern natural product synthesis,chemists are often able to execute two or even multiple chemical reactions to occur in one pot by designing substrate structures and screening reaction conditions,thus to synthesize target molecules in a concise and efficient manner.Such a reaction sequence is termed a cascade reaction.Michael addition and aldol reaction are the two most applied classic reactions in organic synthesis.By regulating the reaction conditions and designing the substrates,they can occur successively in the same system to form complex cyclic systems.This cascade reaction is termed Michael/aldol cascade cyclization reaction,which can effectively improve the atomic and step economy of a synthesis.This review comprises more than 40 reported studies on natural product synthesis as examples to summarize nine common types of Michael/aldol cascade cyclization reactions,to demonstrate their applications as key steps in complex natural product synthesis,and to outlook on the direction of further developments of this methodology.
作者
赵雅宸
俞飚
Zhao Yachen;Yu Biao(School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024;State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032)
出处
《化学学报》
北大核心
2025年第11期1397-1413,共17页
Acta Chimica Sinica
基金
上海市科技计划(No.22YS1401000)资助。
